Synthesis of the Verapamil Intermediate through the Quaternary Carbon-Constructing Allylic Substitution
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DOI: 10.1055/s-0036-1588518
Abstract: In the present study, the key secondary allylic picolinate was synthesized via Pd(PPh3)4-catalyzed coupling of the TBS ether of (R,Z)-4-iodo-5-methylhex-3-en-2-ol with allyl-MgBr. Allylic substitution of the picolinate with the copper reagent derived from 3,4-(MeO)2C6H3MgBr and… read more here.
Keywords: verapamil intermediate; allylic substitution; synthesis verapamil;