Versatile LC-MS-Based Workflow with Robust 0.1 ppm Sensitivity for Identifying Residual HCPs in Biotherapeutic Products.
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DOI: 10.1021/acs.analchem.1c03095
Abstract: Residual host cell proteins (HCPs) in the drug product can affect product quality, stability, and/or safety. In particular, highly active hydrolytic enzymes at sub-ppm levels can negatively impact the shelf life of drug products but… read more here.
Keywords: versatile based; ppm; hcps; based workflow ... See more keywords