Legomedicine—A Versatile Chemo-Enzymatic Approach for the Preparation of Targeted Dual-Labeled Llama Antibody–Nanoparticle Conjugates
Sign Up to like & getrecommendations! Published in 2017 at "Bioconjugate Chemistry"
DOI: 10.1021/acs.bioconjchem.6b00638
Abstract: Conjugation of llama single domain antibody fragments (Variable Heavy chain domains of Heavy chain antibodies, VHHs) to diagnostic or therapeutic nanoparticles, peptides, proteins, or drugs offers many opportunities for optimized targeted cancer treatment. Currently, mostly… read more here.
Keywords: llama; legomedicine versatile; versatile chemo; antibody ... See more keywords
Versatile Chemo-Biocatalytic Cascade Driven by a Thermophilic and Irreversible C–C Bond-Forming α-Oxoamine Synthase
Sign Up to like & getrecommendations! Published in 2023 at "ACS Sustainable Chemistry & Engineering"
DOI: 10.1021/acssuschemeng.3c00243
Abstract: We report a chemo-biocatalytic cascade for the synthesis of substituted pyrroles, driven by the action of an irreversible, thermostable, pyridoxal 5′-phosphate (PLP)-dependent, C–C bond-forming biocatalyst (ThAOS). The ThAOS catalyzes the Claisen-like condensation between various amino… read more here.
Keywords: chemo biocatalytic; versatile chemo; biocatalytic cascade; bond forming ... See more keywords