Engineered Cas12j‐8 is a Versatile Platform for Multiplexed Genome Modulation in Mammalian Cells
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202502593
Abstract: Cas12j‐8 is a compact Cas nuclease discovered from the metagenome of giant bacteriophages, consisting of only 717 amino acids and recognizing the ‘5‐TTN‐3′ protospacer adjacent motif (PAM) sequence. However, its low gene editing efficiency in… read more here.
Keywords: genome modulation; cas12j versatile; engineered cas12j; versatile platform ... See more keywords
Metal-phenolic networks as a versatile platform to engineer nanomaterials and biointerfaces
Sign Up to like & getrecommendations! Published in 2017 at "Nano Today"
DOI: 10.1016/j.nantod.2016.12.012
Abstract: Abstract Surface modification is crucial for conferring novel functionalities to objects and interfaces. However, simple yet versatile strategies for the surface modification of multiple classes of nanomaterials, including biointerfaces, are rare, as the chemical interactions… read more here.
Keywords: platform engineer; metal phenolic; phenolic networks; versatile platform ... See more keywords
5'-End Engineering of CRISPR/Cas12a Activators: A Versatile Platform for Multiple Biomarker Analysis and Clinical Cancer Tissue Identification.
Sign Up to like & getrecommendations! Published in 2025 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.5c03168
Abstract: The CRISPR/Cas12a system has emerged as a powerful tool for biosensing due to its unique trans-cleavage activity. However, the fundamental mechanisms governing its activation remain inadequately understood, limiting the design flexibility and application scope of… read more here.
Keywords: crispr; versatile platform; crispr cas12a; end engineering ... See more keywords
Utilization of Multiple Cloning Site as a Versatile Platform for DNA Triblock Copolymer Synthesis.
Sign Up to like & getrecommendations! Published in 2019 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.9b00503
Abstract: DNA containing block copolymers have utility in a wide range of biomedical applications. However, synthesis of these hybrid materials, especially ones with complex chain structures remains to be a major challenge. Here, we report the… read more here.
Keywords: dna; dna triblock; cloning site; triblock ... See more keywords
A Facile and Versatile Platform for Cytosolic Delivery of Proteins in Nanoshells of DNA or RNA: Packaging Options in Multiplexed Delivery.
Sign Up to like & getrecommendations! Published in 2025 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.5c00149
Abstract: Polyethylenimine (PEI) polymers are used to compact DNA into nanoparticles for delivery into cells. We have shown that PEI-mannose polymers compact DNA into nanoshell-like particles, which can load proteins as well. Here we show that… read more here.
Keywords: platform cytosolic; delivery; facile versatile; versatile platform ... See more keywords
A Versatile Platform for the Development of Radiolabeled Antibody-Recruiting Small Molecules.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00187
Abstract: Building on clinical case reports of the abscopal effect, there has been considerable interest in the synergistic effects of radiation and immunotherapies for the treatment of cancer. Here, the first radiolabeled antibody-recruiting small molecule that… read more here.
Keywords: antibody; radiolabeled antibody; versatile platform; antibody recruiting ... See more keywords
Highly Efficient and para-Selective C-H Functionalization of Polystyrene Providing a Versatile Platform for Diverse Applications.
Sign Up to like & getrecommendations! Published in 2022 at "ACS macro letters"
DOI: 10.1021/acsmacrolett.2c00541
Abstract: Postpolymerization modification of polystyrene (PS) can afford numerous value-added materials with different functions and applications, but it has been hampered by the lack of efficient methods. We report herein a highly efficient and para-selective conversion… read more here.
Keywords: providing versatile; efficient para; versatile platform; highly efficient ... See more keywords
Azobenzene-Integrated NHC Ligands: A Versatile Platform for Visible-Light-Switchable Metal Catalysis.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c01138
Abstract: A new class of photoswitchable NHC ligands, named azImBA, has been developed by integrating azobenzene into a previously unreported imidazobenzoxazol-1-ylidene framework. These rigid photochromic carbenes enable precise control over confinement around a metal's coordination sphere.… read more here.
Keywords: visible light; versatile platform; nhc ligands; azobenzene ... See more keywords
The reductive aromatization of naphthalene diimide: a versatile platform for 2,7-diazapyrenes.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc01937a
Abstract: The reductive aromatization of naphthalene diimide provides tetrapivaloxy-2,7-diazapyrene, which serves as a versatile platform toward peripherally substituted 2,7-diazapyrenes. Time-resolved microwave conductivity measurements demonstrated that the intrinsic electron mobility of 2,7-diazapyrene is significantly higher than that… read more here.
Keywords: naphthalene diimide; aromatization naphthalene; reductive aromatization; versatile platform ... See more keywords
p-GaN gate power HEMT heterostructure as a versatile platform for extremely wide-temperature-range (X-WTR) applications
Sign Up to like & getrecommendations! Published in 2024 at "Applied Physics Letters"
DOI: 10.1063/5.0184784
Abstract: In this work, we manifest that the epitaxial structure for p-GaN gate high-electron-mobility transistor is a versatile platform to develop electronics for operating in an extremely wide temperature range (X-WTR) from 2 to 675 K, with… read more here.
Keywords: temperature; wtr; wide temperature; versatile platform ... See more keywords
A Versatile Platform for Point-of-Care Detection of Molecular Biomarkers
Sign Up to like & getrecommendations! Published in 2024 at "IEEE Sensors Journal"
DOI: 10.1109/jsen.2024.3423678
Abstract: This article presents a point-of-care testing (PoCT) molecular biomarker detection platform based on microfluidics technology. The core of the platform is composed of a miniaturized microfluidic component designed to perform immunoassays for molecular recognition and… read more here.
Keywords: detection; platform; point care; versatile platform ... See more keywords