Efficacy and safety of maintenance therapy with pamiparib versus placebo for advanced gastric cancer responding to first-line platinum-based chemotherapy: Phase 2 study results.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.5997
Abstract: BACKGROUND Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) are approved for the treatment of various solid tumors. In gastric cancer, genes commonly harbor mutations in the homologous recombination DNA repair pathway, potentially increasing sensitivity to PARPi.… read more here.
Keywords: safety; versus placebo; cancer; pamiparib ... See more keywords
IBRUTINIB VERSUS PLACEBO IN PATIENTS WITH ASYMPTOMATIC, TREATMENT‐NAÏVE EARLY STAGE CLL: PRIMARY ENDPOINT RESULTS OF THE PHASE 3 DOUBLE‐BLIND RANDOMIZED CLL12 TRIAL
Sign Up to like & getrecommendations! Published in 2019 at "Hematological Oncology"
DOI: 10.1002/hon.7_2629
Abstract: RCHOP, HR 0.67 (95% CI 0.441.03), p (one-sided) =0.03 (Figure). The 2-year overall survival was 87% and 80%, respectively. Based on COO, PFS HR for R2CHOP was: 0.68 for ABC, p=0.15, 0.86 for GCB, 0.83… read more here.
Keywords: patients asymptomatic; placebo patients; versus placebo; asymptomatic treatment ... See more keywords
HeaLED: Assessment of skin healing under light-emitting diode (LED) exposure-A randomized controlled study versus placebo.
Sign Up to like & getrecommendations! Published in 2021 at "Lasers in surgery and medicine"
DOI: 10.1002/lsm.23480
Abstract: BACKGROUND Light-emitting diodes (LEDs) in the visible or near-infrared spectrum have been reported to promote wound healing. However, despite being frequently proposed in daily clinical practice, the efficacy of photobiomodulation treatment after a laser procedure… read more here.
Keywords: randomized controlled; controlled study; versus placebo; light emitting ... See more keywords
Poor prognostic factors in predicting abatacept response in a phase III randomized controlled trial in psoriatic arthritis
Sign Up to like & getrecommendations! Published in 2020 at "Rheumatology International"
DOI: 10.1007/s00296-020-04564-x
Abstract: In ASTRAEA (NCT01860976), abatacept significantly increased American College of Rheumatology criteria 20% (ACR20) responses at Week 24 versus placebo in patients with psoriatic arthritis (PsA). This post hoc analysis explored relationships between prospectively identified baseline… read more here.
Keywords: psoriatic arthritis; response; poor prognostic; rheumatology ... See more keywords
Improvements in irritability with sertraline versus placebo: Findings from the EMBARC study.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2020.06.021
Abstract: BACKGROUND This report seeks to evaluate improvements in symptoms of irritability with sertraline (a selective serotonin reuptake inhibitor antidepressant) versus placebo. METHODS Participants of Establishing Moderators and Biosignatures of Antidepressant Response in Clinical Care (EMBARC)… read more here.
Keywords: irritability; irritability sertraline; sertraline placebo; versus placebo ... See more keywords
Evaluation of the safety, tolerability, and efficacy of pimavanserin versus placebo in patients with Alzheimer's disease psychosis: a phase 2, randomised, placebo-controlled, double-blind study
Sign Up to like & getrecommendations! Published in 2018 at "The Lancet Neurology"
DOI: 10.1016/s1474-4422(18)30039-5
Abstract: BACKGROUND Pimavanserin is a selective 5-HT2A receptor inverse agonist and antagonist approved in the USA for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis. No safe or effective pharmacological treatment is approved… read more here.
Keywords: alzheimer disease; pimavanserin versus; versus placebo; placebo ... See more keywords
Deepening responses associated with improved progression-free survival with ixazomib versus placebo as posttransplant maintenance in multiple myeloma
Sign Up to like & getrecommendations! Published in 2020 at "Leukemia"
DOI: 10.1038/s41375-020-0819-8
Abstract: In the TOURMALINE-MM3 study, post-autologous stem cell transplantation maintenance therapy with the oral proteasome inhibitor ixazomib versus placebo significantly improved progression-free survival (PFS), with a favorable safety profile. With ixazomib versus placebo maintenance, deepening responses… read more here.
Keywords: ixazomib versus; deepening responses; maintenance; versus placebo ... See more keywords
Eptinezumab for migraine prevention in patients 50 years or older.
Sign Up to like & getrecommendations! Published in 2022 at "Acta neurologica Scandinavica"
DOI: 10.1111/ane.13603
Abstract: OBJECTIVE To evaluate the efficacy and safety of eptinezumab versus placebo in patients ≥50 years old with episodic (EM) or chronic migraine (CM). MATERIALS AND METHODS This post hoc analysis included data from two phase 3,… read more here.
Keywords: placebo; versus placebo; patients years; migraine ... See more keywords
Choto‐san versus placebo for patients with dementia: systematic review and meta‐analysis
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DOI: 10.1111/psyg.12275
Abstract: Choto‐san is a traditional medicine used for hypertension and headaches in Japan and China. Some studies have shown its effectiveness in the treatment of dementia. The present review aimed to assess the effectiveness and acceptability… read more here.
Keywords: choto san; san versus; placebo patients; versus placebo ... See more keywords
Aluminium adjuvants versus placebo or no intervention in vaccine randomised clinical trials: a systematic review with meta-analysis and Trial Sequential Analysis
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Open"
DOI: 10.1136/bmjopen-2021-058795
Abstract: Objectives To assess the benefits and harms of aluminium adjuvants versus placebo or no intervention in randomised clinical trials in relation to human vaccine development. Design Systematic review with meta-analysis and trial sequential analysis assessing… read more here.
Keywords: placebo intervention; adjuvants versus; versus placebo; aluminium adjuvants ... See more keywords
Oral diazoxide versus placebo for severe or recurrent neonatal hypoglycaemia: Neonatal Glucose Care Optimisation (NeoGluCO) study – a randomised controlled trial
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Open"
DOI: 10.1136/bmjopen-2021-059452
Abstract: Introduction Infants with severe or recurrent transitional hypoglycaemia continue to have high rates of adverse neurological outcomes and new treatment approaches are needed that target the underlying pathophysiology. Diazoxide is one such treatment that acts… read more here.
Keywords: trial; versus placebo; severe recurrent; diazoxide versus ... See more keywords