Kinetic versus thermodynamic control of mutational effects on protein homeostasis: A perspective from computational modeling and experiment
Sign Up to like & getrecommendations! Published in 2019 at "Protein Science"
DOI: 10.1002/pro.3639
Abstract: The effect of mutations in individual proteins on protein homeostasis, or “proteostasis,” can in principle depend on the mutations' effects on the thermodynamics or kinetics of folding, or both. Here, we explore this issue using… read more here.
Keywords: protein; versus thermodynamic; protein homeostasis; time ... See more keywords
Kinetic versus thermodynamic metalation enables synthesis of isostructural homo- and heterometallic trinuclear clusters.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc02346a
Abstract: Temperature-dependent metalation of the new hexadentate ligand (tris(5-(pyridin-2-yl)-1H-pyrrol-2-yl)methane; H3TPM) enables the selective synthesis of both mononuclear (i.e. Na(THF)4[Fe(TPM)], kinetic product) and trinuclear (i.e. Fe3(TPM)2, thermodynamic product) complexes. Exposure of Na(THF)4[Fe(TPM)] to FeCl2 or ZnCl2 triggers… read more here.
Keywords: versus thermodynamic; metalation; homo heterometallic; heterometallic trinuclear ... See more keywords