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   Articles with "verteporfin" as a keyword



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The Photosensitising Clinical Agent Verteporfin Is an Inhibitor of SPAK and OSR1 Kinases

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recommendations! Published in 2018 at "ChemBioChem"

DOI: 10.1002/cbic.201800272

Abstract: STE20/SPS1‐related proline/alanine‐rich kinase (SPAK) and oxidative‐stress‐responsive kinase 1 (OSR1) are two serine/threonine protein kinases that play key roles in regulating ion homeostasis. Various SPAK and OSR1 mouse models exhibited reduced blood pressure. Herein, the discovery of… read more here.

Keywords: agent; spak; verteporfin; osr1 kinases ... See more keywords
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Molecular Features of the YAP Inhibitor Verteporfin: Synthesis of Hexasubstituted Dipyrrins as Potential Inhibitors of YAP/TAZ, the Downstream Effectors of the Hippo Pathway

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recommendations! Published in 2017 at "ChemMedChem"

DOI: 10.1002/cmdc.201700063

Abstract: Porphyrin derivatives, in particular verteporfin (VP), a photosensitizer initially designed for cancer therapy, have been identified as inhibitors of the YAP–TEAD interaction and transcriptional activity. Herein we report the efficient convergent synthesis of the dipyrrin… read more here.

Keywords: inhibitors yap; vinyl; verteporfin; yap taz ... See more keywords
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The Role of Verteporfin in Prevention of Periprosthetic Capsular Fibrosis: An Experimental Study.

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recommendations! Published in 2022 at "Aesthetic surgery journal"

DOI: 10.1093/asj/sjac083

Abstract: BACKGROUND Capsular contracture (CC) characterized by excessive fibrosis is one of the most common complications after silicone implant surgery. Verteporfin (VP), as the inhibitor of Yes-associated protein 1 (YAP1), has recently been found to reduce… read more here.

Keywords: periprosthetic capsular; prevention; capsular fibrosis; verteporfin ... See more keywords
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Clinical impact of the worldwide shortage of verteporfin (Visudyne®) on ophthalmic care

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recommendations! Published in 2022 at "Acta Ophthalmologica"

DOI: 10.1111/aos.15148

Abstract: Since July 2021, a worldwide shortage of verteporfin (Visudyne®) occurred: an essential medicine required for photodynamic therapy (PDT). PDT with verteporfin has a broad range of indications in ophthalmology, including chronic central serous chorioretinopathy, polypoidal… read more here.

Keywords: verteporfin visudyne; shortage verteporfin; verteporfin; worldwide shortage ... See more keywords
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The Noninvasive Treatment for Sentinel Lymph Node Metastasis by Photodynamic Therapy Using Phospholipid Polymer as a Nanotransporter of Verteporfin

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recommendations! Published in 2017 at "BioMed Research International"

DOI: 10.1155/2017/7412865

Abstract: Aim. The usefulness of photodynamic therapy (PDT) for treating sentinel lymph node (SLN) metastasis was evaluated. Materials and Methods. Verteporfin, a hydrophobic photosensitizer, forms a soluble aggregate with poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate) (PMB). The concentrations of… read more here.

Keywords: photodynamic therapy; pmb verteporfin; treatment; metastasis ... See more keywords

YAP/TAZ Transcriptional Coactivators Create Therapeutic Vulnerability to Verteporfin in EGFR-mutant Glioblastoma

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recommendations! Published in 2020 at "Clinical Cancer Research"

DOI: 10.1158/1078-0432.ccr-20-0018

Abstract: Purpose: Glioblastomas (GBMs), neoplasms derived from glia and neuroglial progenitor cells, are the most common and lethal malignant primary brain tumors diagnosed in adults, with a median survival of 14 months. GBM tumorigenicity is often… read more here.

Keywords: verteporfin; yap taz; egfr; egfr amplified ... See more keywords
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Abstract 2333: Verteporfin demonstrates antitumoral effect in murine cholangiocarcinoma models

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-2333

Abstract: Cholangiocarcinoma (CCA) is a heterogenous malignancy that is derived from the biliary epithelium. There is growing concern as CCA incidence in United States has steadily increased. Additionally, CCA disproportionately affects different populations, and overall prognosis… read more here.

Keywords: verteporfin demonstrates; antitumoral effect; demonstrates antitumoral; cholangiocarcinoma ... See more keywords
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Verteporfin Inhibits PD-L1 through Autophagy and the STAT1–IRF1–TRIM28 Signaling Axis, Exerting Antitumor Efficacy

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recommendations! Published in 2020 at "Cancer Immunology Research"

DOI: 10.1158/2326-6066.cir-19-0159

Abstract: Antibody blockade of PD-L1 is associated with toxicities, thus new targeting strategies are needed. Verteporfin suppresses PD-L1 expression via Golgi-related autophagy and disruption of STAT1–IRF1–TRIM28 signaling. Programmed cell death 1 ligand 1 (PD-L1) is a… read more here.

Keywords: irf1 trim28; stat1 irf1; trim28 signaling; verteporfin ... See more keywords
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Verteporfin-Loaded Lipid Nanoparticles Improve Ovarian Cancer Photodynamic Therapy In Vitro and In Vivo

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recommendations! Published in 2019 at "Cancers"

DOI: 10.3390/cancers11111760

Abstract: Advanced ovarian cancer is the most lethal gynecological cancer, with a high rate of chemoresistance and relapse. Photodynamic therapy offers new prospects for ovarian cancer treatment, but current photosensitizers lack tumor specificity, resulting in low… read more here.

Keywords: photodynamic therapy; ovarian cancer; verteporfin; cancer ... See more keywords