Abstract 3893: KRAS G12C colon cancer resistance to vertical MAPK inhibition converges on FOS-JUN signaling through orthogonal mechanisms
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DOI: 10.1158/1538-7445.am2023-3893
Abstract: KRAS G12C mutations in cancer can be targeted by G12C-specific inhibitors, but resistance develops rapidly. Preclinical studies suggested multiple drug combinations to improve efficacy, including CDK4/6, MEK, ERK, EGFR, and SHP2 inhibitors, collectively called vertical… read more here.
Keywords: kras g12c; cancer; vertical mapk; resistance ... See more keywords