Dual function of PI(4,5)P2 in insulin-regulated exocytic trafficking of GLUT4 in adipocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.06.019
Abstract: Phosphoinositides are important signaling molecules involved in the regulation of vesicular trafficking. It has been implicated that phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] is involved in insulin-regulated GLUT4 translocation in adipocytes. However, it remains unclear where and how… read more here.
Keywords: insulin; vesicle; trafficking; vesicle docking ... See more keywords
Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms15293
Abstract: The presynaptic active zone protein Munc13 is essential for neurotransmitter release, playing key roles in vesicle docking and priming. Mechanistically, it is thought that the C2A domain of Munc13 inhibits the priming function by homodimerization,… read more here.
Keywords: vesicle docking; docking priming; c2a domain; munc13 ... See more keywords