Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13754
Abstract: Declining nicotinamide adenine dinucleotide (NAD+) concentration in the brain during aging contributes to metabolic and cellular dysfunction and is implicated in the pathogenesis of aging‐associated neurological disorders. Experimental therapies aimed at boosting brain NAD+ levels… read more here.
Keywords: plasma extracellular; extracellular vesicles; pathology; vesicles enriched ... See more keywords
Extracellular vesicles enriched with amylin receptor are cytoprotective against the Aß toxicity in vitro
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0267164
Abstract: Extracellular vesicles (EVs) are double membrane structures released by all cell types with identified roles in the generation, transportation, and degradation of amyloid-β protein (Aβ) oligomers in Alzheimer’s disease (AD). EVs are thus increasingly recognized… read more here.
Keywords: enriched amylin; vesicles enriched; receptor cytoprotective; cytoprotective toxicity ... See more keywords