Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
Sign Up to like & getrecommendations! Published in 2025 at "FEBS Letters"
DOI: 10.1002/1873-3468.70166
Abstract: The protective effects of imeglimin, a recently approved antidiabetic agent, against liver fibrosis have not been previously evaluated. In this study, we demonstrated that 8‐week administration of imeglimin attenuated immune cell infiltration and reduced collagen… read more here.
Keywords: liver fibrosis; atp release; atp; hepatic stellate ... See more keywords
Fluorescent Labeling and Quantification of Vesicular ATP Release Using Live Cell Imaging.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9717-6_15
Abstract: Adenosine triphosphate (ATP) is actively transported into vesicles for purinergic neurotransmission by the vesicular nucleotide transporter, VNUT, encoded by the gene, solute carrier 17, member 9 (SLC17A9). In this chapter, methods are described for fluorescent… read more here.
Keywords: vesicular atp; atp; live cell; atp release ... See more keywords
Study of vesicular ATP release is complicated by Golgi-sequestered VNUT-pHluorins and clondronate inhibiting ATP release mediated by cell lysis in Neuro2A cells
Sign Up to like & getrecommendations! Published in 2025 at "Physiology"
DOI: 10.1152/physiol.2025.40.s1.1799
Abstract: Introduction: Vesicular ATP release mediates neurotransmission and paracrine signalling in diverse tissues systems, and the Vesicular Nucleotide Transporter (VNUT / SLC17A9) was identified as the transporter that loads ATP into vesicles. In many tissues, like… read more here.
Keywords: physiology; release; vnut; atp release ... See more keywords