Deletion of the vesicular monoamine transporter 1 (vmat1/slc18a1) gene affects dopamine signaling
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research"
DOI: 10.1016/j.brainres.2019.01.029
Abstract: The vesicular monoamine transporter is involved in presynaptic catecholamine storage and neurotransmission. Two isoforms of the transporter exist, VMAT1 and VMAT2, and both are expressed in the brain, though VMAT2 expression is more robust and… read more here.
Keywords: monoamine transporter; vesicular monoamine; expression; vmat1 ... See more keywords
Synthesis and analysis of dihydrotetrabenazine derivatives as novel vesicular monoamine transporter 2 inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113718
Abstract: Vesicular monoamine transporter 2 (VMAT2) is essential for synaptic transmission of all biogenic amines in the brain including serotonin, norepinephrine, histamine, and dopamine (DA). Given its crucial role in the neurophysiology and pharmacology of the… read more here.
Keywords: monoamine transporter; vesicular monoamine; synthesis analysis; dihydrotetrabenazine ... See more keywords
Association study of the vesicular monoamine transporter 1 (VMAT1) gene with autism in an Iranian population.
Sign Up to like & getrecommendations! Published in 2017 at "Gene"
DOI: 10.1016/j.gene.2017.05.003
Abstract: Autism Spectrum Disorders (ASD) (MIM 209850) are a group of neurodevelopmental disorders distinguished by destructed social interaction and communication abilities along with peculiar repetitive behavior. Several genetic loci have been linked to this disorder. Vesicular… read more here.
Keywords: transporter vmat1; vesicular monoamine; vmat1; monoamine transporter ... See more keywords
Vesicular monoamine transporter 1 gene polymorphism and white matter integrity in major depressive disorder
Sign Up to like & getrecommendations! Published in 2017 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2017.02.028
Abstract: ABSTRACT The genetic variant of the vesicular monoamine transporter 1 gene (VMAT1) has been suggested to be associated with monoaminergic signaling and neural circuit activity related to emotion processing. We aimed to investigate microstructural changes… read more here.
Keywords: matter; vesicular monoamine; matter integrity; gene ... See more keywords
Mechanism of action of vesicular monoamine transporter 2 (VMAT2) inhibitors in tardive dyskinesia: reducing dopamine leads to less “go” and more “stop” from the motor striatum for robust therapeutic effects
Sign Up to like & getrecommendations! Published in 2017 at "CNS Spectrums"
DOI: 10.1017/s1092852917000621
Abstract: Tardive dyskinesia can now be successfully treated by inhibiting the vesicular monoamine transporter type 2 (VMAT2). read more here.
Keywords: monoamine transporter; vesicular monoamine; tardive dyskinesia;
Classics in Neuroimaging: Radioligands for the Vesicular Monoamine Transporter 2.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.8b00429
Abstract: Positron emission tomography (PET) studies of the monoamine neurotransmitter systems in the human brain employ a variety of radiotracers targeting the many receptors, transporters, and enzymes present in monoaminergic neurons. One of these is the… read more here.
Keywords: monoamine transporter; vesicular monoamine; neuroimaging radioligands; classics neuroimaging ... See more keywords
Genetic Variation in the Vesicular Monoamine Transporter: Preliminary Associations With Cognitive Outcomes After Severe Traumatic Brain Injury
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Head Trauma Rehabilitation"
DOI: 10.1097/htr.0000000000000224
Abstract: Introduction: Traumatic brain injury (TBI) frequently results in impaired cognition, a function that can be modulated by monoaminergic signaling. Genetic variation among monoaminergic genes may affect post-TBI cognitive performance. The vesicular monoamine transporter-2 (VMAT2) gene… read more here.
Keywords: cognitive outcomes; traumatic brain; variation; vesicular monoamine ... See more keywords
Vesicular monoamine transporter 2 mediates fear behavior in mice
Sign Up to like & getrecommendations! Published in 2020 at "Genes"
DOI: 10.1111/gbb.12634
Abstract: A subset of people exposed to a traumatic event develops post‐traumatic stress disorder (PTSD), which is associated with dysregulated fear behavior. Genetic variation in SLC18A2, the gene that encodes vesicular monoamine transporter 2 (VMAT2), has… read more here.
Keywords: vmat2 mice; fear behavior; vesicular monoamine; mice ... See more keywords
Diagnostic accuracy of imaging brain vesicular monoamine transporter type 2 (VMAT2) in clinically uncertain parkinsonian syndrome (CUPS): a 3-year follow-up study in community patients
Sign Up to like & getrecommendations! Published in 2018 at "BMJ Open"
DOI: 10.1136/bmjopen-2018-025533
Abstract: Objectives To further validate the diagnostic utility of 18F-AV-133 vesicular monoamine transporter type 2 (VMAT2) positron emission tomography (PET) in patients with clinically uncertain parkinsonian syndromes (CUPS) by comparison to clinical diagnosis at 3 years… read more here.
Keywords: 133 pet; diagnosis; study; vesicular monoamine ... See more keywords