Bifunctional Therapeutic Peptide Assembled Nanoparticles Exerting Improved Activities of Tumor Vessel Normalization and Immune Checkpoint Inhibition.
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DOI: 10.1002/adhm.202100051
Abstract: The effectiveness of cancer immunotherapy is impaired by the dysfunctional vasculature of tumors. Created hypoxia zones and limited delivery of cytotoxic immune cells help to have immune resistance in tumor tissue. Structural and functional normalization… read more here.
Keywords: immune checkpoint; peptide; vessel normalization; tumor ... See more keywords
Supramolecular Nitric Oxide Depot for Hypoxic Tumor Vessel Normalization and Radiosensitization
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DOI: 10.1002/adma.202202625
Abstract: In cancer radiotherapy, the lack of fixed DNA damage by oxygen in hypoxic microenvironment of solid tumors often leads to severe radioresistance. Nitric oxide (NO) is a potent radiosensitizer that acts in two ways. It… read more here.
Keywords: hypoxic tumor; normalization radiosensitization; tumor vessel; nitric oxide ... See more keywords
Combination of tumor vessel normalization and immune checkpoint blockade for breast cancer treatment via multifunctional nanocomplexes.
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DOI: 10.1039/d2bm00600f
Abstract: Tumor vessel normalization can alleviate hypoxia, reduce the intratumoral infiltration of immunosuppressive cells and increase the intratumoral infiltration of immune effector cells (CD8+ T cells), further reversing the immunosuppressive microenvironment. Here, nanocomplexes (lipo/St@FA-COSA/BMS-202) which can… read more here.
Keywords: tumor; tumor vessel; bms 202; vessel normalization ... See more keywords
Antiangiogenesis: Vessel Regression, Vessel Normalization, or Both?
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DOI: 10.1158/0008-5472.can-21-3515
Abstract: The concepts of antiangiogenic tumor therapy were pioneered on the assumption that the inhibition of tumor angiogenesis should lead to the complete regression of the tumor-associated vasculature and thereby hold the tumor in an avascular… read more here.
Keywords: vessel regression; vessel normalization; tumor;
Galectin-1 Inhibitor OTX008 Induces Tumor Vessel Normalization and Tumor Growth Inhibition in Human Head and Neck Squamous Cell Carcinoma Models
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DOI: 10.3390/ijms18122671
Abstract: Galectin-1 is a hypoxia-regulated protein and a prognostic marker in head and neck squamous cell carcinomas (HNSCC). Here we assessed the ability of non-peptidic galectin-1 inhibitor OTX008 to improve tumor oxygenation levels via tumor vessel… read more here.
Keywords: tumor growth; vessel normalization; galectin inhibitor; tumor ... See more keywords
Oridonin inhibits tumor angiogenesis and induces vessel normalization in experimental colon cancer
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DOI: 10.7150/jca.55929
Abstract: Purpose: Tumor blood vessels exhibit morphological and functional aberrancies. Its maturity and functionality are closely associated with colon cancer progression and therapeutic efficacy. The direct evidence proving whether oridonin (ORI) has vascular normalization promoting effect… read more here.
Keywords: vessel normalization; angiogenesis; colon cancer; cancer ... See more keywords