Vessel co-option and angiotropic extravascular migratory metastasis: a continuum of tumour growth and spread?
Sign Up to like & getrecommendations! Published in 2022 at "British journal of cancer"
DOI: 10.1038/s41416-021-01686-2
Abstract: Two fields of cancer research have emerged dealing with the biology of tumour cells localised to the abluminal vascular surface: vessel co-option (VCo), a non-angiogenic mode of tumour growth and angiotropic extravascular migratory metastasis (EVMM),… read more here.
Keywords: cancer; tumour growth; angiotropic extravascular; vessel option ... See more keywords
Angiogenesis in NSCLC: is vessel co-option the trunk that sustains the branches?
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DOI: 10.18632/oncotarget.7794
Abstract: The critical role of angiogenesis in tumor development makes its inhibition a valuable new approach in therapy, rapidly making anti-angiogenesis a major focus in research. While the VEGF/VEGFR pathway is the main target of the… read more here.
Keywords: angiogenesis; vessel; anti angiogenic; vessel option ... See more keywords
Angiogenesis and Resistance Mechanisms in Glioblastoma: Targeting Alternative Vascularization Pathways to Overcome Therapy Resistance.
Sign Up to like & getrecommendations! Published in 2025 at "Current pharmaceutical design"
DOI: 10.2174/0113816128367551250703122830
Abstract: INTRODUCTION Glioblastoma (GBM), the most aggressive form of primary brain tumor in adults, remains a significant clinical challenge due to its high recurrence and poor prognosis. Characterized by rapid growth, invasiveness, and resistance to therapy,… read more here.
Keywords: resistance; therapy; angiogenesis; tumor ... See more keywords
Tumor vessel co-option: The past & the future
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DOI: 10.3389/fonc.2022.965277
Abstract: Tumor vessel co-option (VCO) is a non-angiogenic vascularization mechanism that is a possible cause of resistance to anti-angiogenic therapy (AAT). Multiple tumors are hypothesized to primarily rely on growth factor signaling-induced sprouting angiogenesis, which is… read more here.
Keywords: tumor; tumor vessel; biology; vessel option ... See more keywords
Angiopoietin-1 Upregulates Cancer Cell Motility in Colorectal Cancer Liver Metastases through Actin-Related Protein 2/3
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DOI: 10.3390/cancers14102540
Abstract: Simple Summary Vessel co-option has been recognized as a mechanism associated with resistance to anti-angiogenic treatment in colorectal cancer liver metastases (CRCLMs). Recently, we reported that Angiopoietin-1 (Ang1) stimulates vessel co-option in CRCLM through an… read more here.
Keywords: crclm; liver; cancer; vessel option ... See more keywords
The Inhibition of Vessel Co-Option as an Emerging Strategy for Cancer Therapy
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DOI: 10.3390/ijms25020921
Abstract: Vessel co-option (VCO) is a non-angiogenic mechanism of vascularization that has been associated to anti-angiogenic therapy. In VCO, cancer cells hijack the pre-existing blood vessels and use them to obtain oxygen and nutrients and invade… read more here.
Keywords: cancer; therapy; blood vessels; vessel option ... See more keywords