CB1 Receptor Activation on VgluT2-Expressing Glutamatergic Neurons Underlies Δ9-Tetrahydrocannabinol (Δ9-THC)-Induced Aversive Effects in Mice
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DOI: 10.1038/s41598-017-12399-z
Abstract: Cannabis can be rewarding or aversive. Cannabis reward is believed to be mediated by activation of cannabinoid CB1 receptors (CB1Rs) on GABAergic neurons that disinhibit dopaminergic neurons in the ventral tegmental area (VTA). However, little… read more here.
Keywords: vglut2 expressing; tetrahydrocannabinol thc; glutamatergic neurons; aversive effects ... See more keywords
Optogenetic activation of VGLUT2-expressing excitatory neurons blocks epileptic seizure-like activity in the mouse entorhinal cortex
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DOI: 10.1038/srep43230
Abstract: We investigated whether an anti-epileptic effect is obtained by selectively activating excitatory neurons expressing ChR2 under the promoter for the synaptic vesicular glutamate transporter 2 (VGLUT2). VGLUT2-expressing cells were optically stimulated while local field potential… read more here.
Keywords: seizure like; excitatory neurons; vglut2 expressing; like activity ... See more keywords