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   Articles with "vhh" as a keyword



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Characterization of a putative maltodextrin-binding protein of Streptococcus pyogenes, SPs0871 and the development of a VHH inhibitor.

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recommendations! Published in 2021 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2021.05.056

Abstract: Streptococcus pyogenes causes a wide range of human infections. Currently, antibiotics are the main treatment for S. pyogenes infection, but serious anti-microbial resistance requires alternative treatment options. To develop a novel strategy for treatment, we physicochemically… read more here.

Keywords: streptococcus pyogenes; development vhh; vhh; binding protein ... See more keywords
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Simplified monomeric VHH-Fc antibodies provide new opportunities for passive immunization.

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recommendations! Published in 2019 at "Current opinion in biotechnology"

DOI: 10.1016/j.copbio.2019.11.006

Abstract: Simplified monomeric monoclonal antibodies consisting of a single-domain VHH, derived from camelid heavy-chain only antibodies, fused with the Fc domain of either IgG (VHH-IgG) or IgA (VHH-IgA) antibodies, are promising therapeutic proteins. These simplified single-gene… read more here.

Keywords: vhh antibodies; monomeric vhh; simplified monomeric; vhh ... See more keywords
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Single VHH-directed BCMA CAR-T cells cause remission of relapsed/refractory multiple myeloma

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recommendations! Published in 2021 at "Leukemia"

DOI: 10.1038/s41375-021-01269-3

Abstract: Chimeric antigen receptor T (CAR-T) cells have shown remarkable effects in treating hematological malignancies [1, 2]. Typically, the antigen recognition domain of CAR-T cells is a single-chain variable fragment (scFv) linked to a costimulatory domain… read more here.

Keywords: chain; heavy chain; bcma; vhh ... See more keywords
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GlycoVHH: optimal sites for introducing N-glycans on the camelid VHH antibody scaffold and use for macrophage delivery

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recommendations! Published in 2023 at "mAbs"

DOI: 10.1080/19420862.2023.2210709

Abstract: ABSTRACT As small and stable high-affinity antigen binders, VHHs boast attractive characteristics both for therapeutic use in various disease indications, and as versatile reagents in research and diagnostics. To further increase the versatility of VHHs,… read more here.

Keywords: vhh; glycovhh optimal; macrophage; optimal sites ... See more keywords
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An alpaca single-domain antibody (VHH) phage-display library constructed by CDR shuffling provided high affinity VHHs against desired protein antigens.

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recommendations! Published in 2022 at "International immunology"

DOI: 10.1093/intimm/dxac022

Abstract: Antigen combining sites of the camelid heavy chain antibody variable domain (VHH) are constructed by three complementarity determining regions (CDR1, CDR2, and CDR3). We prepared cDNA using mRNA extracted from peripheral lymphocytes of alpacas that… read more here.

Keywords: display library; vhh; vhh phage; protein antigens ... See more keywords
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Neoleukin-2 enhances anti-tumour immunity downstream of peptide vaccination targeted by an anti-MHC class II VHH

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recommendations! Published in 2020 at "Open Biology"

DOI: 10.1098/rsob.190235

Abstract: Cancer-specific mutations can lead to peptides of unique sequence presented on MHC class I to CD8 T cells. These neoantigens can be potent tumour-rejection antigens, appear to be the driving force behind responsiveness to anti-CTLA-4… read more here.

Keywords: enhances anti; cd8; class; neoleukin enhances ... See more keywords
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Development of Nanobodies as Theranostic Agents against CMY-2-Like Class C β-Lactamases

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recommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1101/2022.07.01.498528

Abstract: Three soluble single-domain fragments derived from the unique variable region of camelid heavy-chain antibodies (VHHs) against the CMY-2 β-lactamase behaved as inhibitors. The structure of the complex VHH cAbCMY-2(254)/CMY-2 showed that the epitope is close… read more here.

Keywords: vhh; development; class; cmy ... See more keywords
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AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model

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recommendations! Published in 2022 at "EMBO Molecular Medicine"

DOI: 10.15252/emmm.201809824

Abstract: Single domain antibodies (VHHs) are potentially disruptive therapeutics, with important biological value for treatment of several diseases, including neurological disorders. However, VHHs have not been widely used in the central nervous system (CNS), largely because… read more here.

Keywords: vhh; aav; alzheimer disease; bace1 ... See more keywords
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Super Potent Bispecific Llama VHH Antibodies Neutralize HIV via a Combination of gp41 and gp120 Epitopes

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recommendations! Published in 2019 at "Antibodies"

DOI: 10.3390/antib8020038

Abstract: Broad and potent neutralizing llama single domain antibodies (VHH) against HIV-1 targeting the CD4 binding site (CD4bs) have previously been isolated upon llama immunization. Here we describe the epitopes of three additional VHH groups selected… read more here.

Keywords: super potent; combination; group; gp41 ... See more keywords
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Large-Scale Production of Anti-RNase A VHH Expressed in pyrG Auxotrophic Aspergillus oryzae

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recommendations! Published in 2023 at "Current Issues in Molecular Biology"

DOI: 10.3390/cimb45060304

Abstract: Nanobodies, also referred to as VHH antibodies, are the smallest fragments of naturally produced camelid antibodies and are ideal affinity reagents due to their remarkable properties. They are considered an alternative to monoclonal antibodies (mAbs)… read more here.

Keywords: vhh; pyrg auxotrophic; large scale; rnase ... See more keywords
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One-step Preparation of a VHH-based Immunoadsorbent for the Extracorporeal Removal of β2-microglobulin

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recommendations! Published in 2019 at "Molecules"

DOI: 10.3390/molecules24112119

Abstract: Dialysis-related amyloidosis (DRA), which has been widely recognized to be associated with the accumulation of β2-microglobulin (β2-m) in blood, is one of the most common complications in patients receiving long-term dialysis treatment. The most significant… read more here.

Keywords: step preparation; vhh; blood; one step ... See more keywords