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   Articles with "vhh" as a keyword



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Characterization of a putative maltodextrin-binding protein of Streptococcus pyogenes, SPs0871 and the development of a VHH inhibitor.

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recommendations! Published in 2021 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2021.05.056

Abstract: Streptococcus pyogenes causes a wide range of human infections. Currently, antibiotics are the main treatment for S. pyogenes infection, but serious anti-microbial resistance requires alternative treatment options. To develop a novel strategy for treatment, we physicochemically… read more here.

Keywords: streptococcus pyogenes; development vhh; vhh; binding protein ... See more keywords
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Simplified monomeric VHH-Fc antibodies provide new opportunities for passive immunization.

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recommendations! Published in 2019 at "Current opinion in biotechnology"

DOI: 10.1016/j.copbio.2019.11.006

Abstract: Simplified monomeric monoclonal antibodies consisting of a single-domain VHH, derived from camelid heavy-chain only antibodies, fused with the Fc domain of either IgG (VHH-IgG) or IgA (VHH-IgA) antibodies, are promising therapeutic proteins. These simplified single-gene… read more here.

Keywords: vhh antibodies; monomeric vhh; simplified monomeric; vhh ... See more keywords

Genetic Engineering of VHH Antibody Fragments for Efficient Site-Specific Conjugation to Polysaccharides

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recommendations! Published in 2025 at "Bioconjugate Chemistry"

DOI: 10.1021/acs.bioconjchem.5c00167

Abstract: Site-selective modifications of proteins, without compromising their biological activity, are highly sought after due to their critical role in many biomedical applications. Here, we established a universal and efficient approach for site-selective conjugation of a… read more here.

Keywords: cys; chemistry; efficiency; conjugation ... See more keywords

Engineering a Low-Immunogenic Mirror-Image VHH against Vascular Endothelial Growth Factor.

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recommendations! Published in 2024 at "ACS chemical biology"

DOI: 10.1021/acschembio.4c00197

Abstract: Immunogenicity is a major caveat of protein therapeutics. In particular, the long-term administration of protein therapeutic agents leads to the generation of antidrug antibodies (ADAs), which reduce drug efficacy while eliciting adverse events. One promising… read more here.

Keywords: vascular endothelial; mirror image; image; vegf ... See more keywords

Single VHH-directed BCMA CAR-T cells cause remission of relapsed/refractory multiple myeloma

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recommendations! Published in 2021 at "Leukemia"

DOI: 10.1038/s41375-021-01269-3

Abstract: Chimeric antigen receptor T (CAR-T) cells have shown remarkable effects in treating hematological malignancies [1, 2]. Typically, the antigen recognition domain of CAR-T cells is a single-chain variable fragment (scFv) linked to a costimulatory domain… read more here.

Keywords: chain; heavy chain; bcma; vhh ... See more keywords

GlycoVHH: optimal sites for introducing N-glycans on the camelid VHH antibody scaffold and use for macrophage delivery

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recommendations! Published in 2023 at "mAbs"

DOI: 10.1080/19420862.2023.2210709

Abstract: ABSTRACT As small and stable high-affinity antigen binders, VHHs boast attractive characteristics both for therapeutic use in various disease indications, and as versatile reagents in research and diagnostics. To further increase the versatility of VHHs,… read more here.

Keywords: vhh; glycovhh optimal; macrophage; optimal sites ... See more keywords

An alpaca single-domain antibody (VHH) phage-display library constructed by CDR shuffling provided high affinity VHHs against desired protein antigens.

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recommendations! Published in 2022 at "International immunology"

DOI: 10.1093/intimm/dxac022

Abstract: Antigen combining sites of the camelid heavy chain antibody variable domain (VHH) are constructed by three complementarity determining regions (CDR1, CDR2, and CDR3). We prepared cDNA using mRNA extracted from peripheral lymphocytes of alpacas that… read more here.

Keywords: display library; vhh; vhh phage; protein antigens ... See more keywords

206 Evaluation of the effect of oral administration of bivalent VHH constructs in weaned piglets challenged with enterotoxigenic Escherichia coli F4+

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recommendations! Published in 2024 at "Journal of Animal Science"

DOI: 10.1093/jas/skae102.002

Abstract: Following the European restriction on the use of antibiotics and zinc oxide (ZnO) in livestock, the search for novel and sustainable strategies to reduce the incidence of enteric infections in piglets caused by Escherichia coli… read more here.

Keywords: bivalent vhh; zno vhh; vhh constructs; vhh ... See more keywords
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Neoleukin-2 enhances anti-tumour immunity downstream of peptide vaccination targeted by an anti-MHC class II VHH

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recommendations! Published in 2020 at "Open Biology"

DOI: 10.1098/rsob.190235

Abstract: Cancer-specific mutations can lead to peptides of unique sequence presented on MHC class I to CD8 T cells. These neoantigens can be potent tumour-rejection antigens, appear to be the driving force behind responsiveness to anti-CTLA-4… read more here.

Keywords: enhances anti; cd8; class; neoleukin enhances ... See more keywords

Development of Nanobodies as Theranostic Agents against CMY-2-Like Class C β-Lactamases

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recommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1101/2022.07.01.498528

Abstract: Three soluble single-domain fragments derived from the unique variable region of camelid heavy-chain antibodies (VHHs) against the CMY-2 β-lactamase behaved as inhibitors. The structure of the complex VHH cAbCMY-2(254)/CMY-2 showed that the epitope is close… read more here.

Keywords: vhh; development; class; cmy ... See more keywords

Effects of a 6-Week Repeated-Sprint Training With Voluntary Hypoventilation at Low and High Lung Volume on Repeated-Sprint Ability in Female Soccer Players.

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recommendations! Published in 2024 at "International journal of sports physiology and performance"

DOI: 10.1123/ijspp.2023-0392

Abstract: PURPOSE To investigate the effects of repeated-sprint training with voluntary hypoventilation at low (RSH-VHL) and high (RS-VHH) lung volume on repeated-sprint ability (RSA) in female athletes. METHODS Over a 6-week period, 24 female soccer players… read more here.

Keywords: rsh vhl; training voluntary; repeated sprint; vhh ... See more keywords