An alpaca single-domain antibody (VHH) phage-display library constructed by CDR shuffling provided high affinity VHHs against desired protein antigens.
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DOI: 10.1093/intimm/dxac022
Abstract: Antigen combining sites of the camelid heavy chain antibody variable domain (VHH) are constructed by three complementarity determining regions (CDR1, CDR2, and CDR3). We prepared cDNA using mRNA extracted from peripheral lymphocytes of alpacas that… read more here.
Keywords: display library; vhh; vhh phage; protein antigens ... See more keywords