Interaction with p53 explains a pro-proliferative function for VHL in cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-020-01951-6
Abstract: The von Hippel-Lindau (VHL) protein binds and degrades hypoxia-inducible factors (HIF) hydroxylated by prolyl-hydroxylases under normoxia. Although originally described as a tumor suppressor, there is growing evidence that VHL may paradoxically promote tumor growth. The… read more here.
Keywords: vhl; hif; target; function ... See more keywords
Hemangioblastoma and von Hippel-Lindau disease: genetic background, spectrum of disease, and neurosurgical treatment
Sign Up to like & getrecommendations! Published in 2020 at "Child's Nervous System"
DOI: 10.1007/s00381-020-04712-5
Abstract: Introduction Hemangioblastomas are rare, histologically benign, highly vascularized tumors of the brain, the spinal cord, and the retina, occurring sporadically or associated with the autosomal dominant inherited von Hippel-Lindau (VHL) disease. Children or adults with… read more here.
Keywords: vhl; hippel lindau; disease; von hippel ... See more keywords
An efficient strategy for digging protein-protein interactions for rational drug design - A case study with HIF-1α/VHL.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113871
Abstract: The ubiquitination of the hypoxia-inducible factor-1α (HIF-1α) is mediated by interacting with the von Hippel-Lindau protein (VHL), and is associated with cancer, chronic anemia, and ischemia. VHL, an E3 ligase, has been reported to degrade… read more here.
Keywords: hif; vhl; protein protein; hif vhl ... See more keywords
Characterization of VHL promoter variants in patients suspected of Von Hippel-Lindau disease.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medical genetics"
DOI: 10.1016/j.ejmg.2018.07.006
Abstract: Von Hippel-Lindau (VHL) disease is a hereditary tumor syndrome in which carriers are at an increased risk of developing a variety of tumors in multiple organ systems. A clinical diagnosis of VHL is determined by… read more here.
Keywords: vhl; hippel lindau; von hippel; promoter variants ... See more keywords
Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.8b00842
Abstract: Beyond the targeting of E3 ubiquitin ligases to inhibit protein homeostasis, E3 ligase binders can be repurposed as targeted protein degraders (PROTACs or molecular glues). We sought to identify new binders of the VHL E3… read more here.
Keywords: vhl; fragment based; surface probing; ligase ... See more keywords
Discovery of SIAIS178 as an effective BCR-ABL degrader by recruiting von Hippel-Lindau (VHL) E3 Ubiquitin Ligase.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b01264
Abstract: The oncogenic fusion protein BCR-ABL is the driving force of leukemogenesis in chronic myeloid leukemia (CML). Despite great progress for CML treatment through application of tyrosine kinase inhibitors (TKIs) against BCR-ABL, long-term drug administration and… read more here.
Keywords: vhl; bcr; siais178; bcr abl ... See more keywords
RalBP1 and p19-VHL play an oncogenic role, and p30-VHL plays a tumor suppressor role during the blebbishield emergency program
Sign Up to like & getrecommendations! Published in 2017 at "Cell Death Discovery"
DOI: 10.1038/cddiscovery.2017.23
Abstract: Cancer stem cells evade apoptotic death by blebbishield emergency program, which constructs blebbishields from apoptotic bodies and drives cellular transformation. Von Hippel–Lindau (VHL) plays both tumor suppressor and oncogenic roles, and the reason behind is… read more here.
Keywords: vhl; blebbishield; tumor suppressor; vhl plays ... See more keywords
Pancreas and Biliary Tree
Sign Up to like & getrecommendations! Published in 2017 at "Modern Pathology"
DOI: 10.1038/modpathol.2016.259
Abstract: 1765 Hemangioblastoma: A Targeted Next Generation Sequencing Study Esther C Yoon, Jian Zhuge, George Kleinman, John T Fallon, Minghao Zhong. New York Medical College at Westchester Medical Center, Valhalla, NY. Background: Hemangioblastomas (HB) are rare… read more here.
Keywords: vhl; vhl mutation; study; pancreas biliary ... See more keywords
Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Society Reviews"
DOI: 10.1039/d2cs00387b
Abstract: The von Hippel-Lindau (VHL) Cullin RING E3 ligase is an essential enzyme in the ubiquitin-proteasome system that recruits substrates such as the hypoxia inducible factor for ubiquitination and subsequent proteasomal degradation. The ubiquitin-proteasome pathway can… read more here.
Keywords: small molecule; molecule ligands; von hippel; protac degraders ... See more keywords
Is ultra wide-field retinal imaging alone appropriate for retinal angioma screening in lower risk subjects attending Von Hippel-Lindau (VHL) clinics?
Sign Up to like & getrecommendations! Published in 2019 at "Ophthalmic Genetics"
DOI: 10.1080/13816810.2019.1678177
Abstract: ABSTRACT Purpose: To determine if non-mydriatic ultra wide-angle digital retinal imaging alone is effective for screening subjects considered to be at 50% or lower risk for developing retinal angiomas. Methods: Digital records and retinal images… read more here.
Keywords: ultra wide; vhl; risk; retinal imaging ... See more keywords
Investigation of germline VHL variants in Iranian patients with retinal capillary hemangioblastoma and genotype-phenotype analysis
Sign Up to like & getrecommendations! Published in 2023 at "Ophthalmic Genetics"
DOI: 10.1080/13816810.2022.2138455
Abstract: ABSTRACT Background Retinal capillary hemangioblastoma (RCH), while sporadic in some cases, is the most common and earliest manifestation of von Hippel-Lindau disease (VHL). This is the first report on different types of VHL variants and… read more here.
Keywords: retinal capillary; capillary hemangioblastoma; vhl variants; genotype phenotype ... See more keywords