ARF6 Promotes AML Progression via Activation of PI3K/AKT/mTOR Signaling
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Medicine"
DOI: 10.1002/cam4.70872
Abstract: Acute myeloid leukemia (AML) represents a highly aggressive hematological malignancy characterized by a poor prognosis and a pressing demand for innovative diagnostic and prognostic biomarkers. Recent studies have indicated that ADP‐ribosylation factor 6 (ARF6) is… read more here.
Keywords: promotes aml; via activation; activation pi3k; arf6 promotes ... See more keywords
Anthocyanin oligomers stimulate browning in 3T3‐L1 white adipocytes via activation of the β3‐adrenergic receptor and ERK signaling pathway
Sign Up to like & getrecommendations! Published in 2021 at "Phytotherapy Research"
DOI: 10.1002/ptr.7276
Abstract: Microbial fermentation of grape‐skin extracts is found to synthesize anthocyanin oligomers (AO), which are more active than the monomeric anthocyanins that are effective for some metabolic diseases such as diabetes and obesity. This study investigated… read more here.
Keywords: anthocyanin oligomers; white adipocytes; 3t3 white; treatment ... See more keywords
Triiodothyronine (T3) enhances lifespan and protects against oxidative stress via activation of Klotho in Caenorhabditis elegans.
Sign Up to like & getrecommendations! Published in 2021 at "Biogerontology"
DOI: 10.1007/s10522-021-09923-0
Abstract: Age predisposes individuals to significant diseases, and the biological processes contributing to aging are currently under intense investigation. Klotho is an anti-aging protein with multifaceted roles and is an essential component of the endocrine fibroblast… read more here.
Keywords: activation klotho; caenorhabditis elegans; activation; via activation ... See more keywords
Lemon juice catalyzed C–C bond formation via C–H activation of methylarene: a sustainable synthesis of chromenopyrimidines
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Diversity"
DOI: 10.1007/s11030-019-09980-1
Abstract: Abstract An economical and proficient approach has been developed for the synthesis of chromenopyrimidines via three-component reaction of thiobarbituric acid/barbituric acid, methylarenes and dimedone/1,3-cyclohexanedione by using lemon juice as a natural, biodegradable catalyst and TBHP… read more here.
Keywords: formation via; lemon juice; bond formation; synthesis chromenopyrimidines ... See more keywords
Deltamethrin induces liver fibrosis in quails via activation of the TGF-β1/Smad signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental pollution"
DOI: 10.1016/j.envpol.2019.113870
Abstract: Deltamethrin (DLM) is an important member of the pyrethroid pesticide family, and its widespread use has led to serious environmental and health problems. Exposure to DLM causes pathological changes in the liver of animals and… read more here.
Keywords: fibrosis quails; activation tgf; liver fibrosis; tgf smad ... See more keywords
Hydride–Rhodium(III)-N-Heterocyclic Carbene Catalyst for Tandem Alkylation/Alkenylation via C–H Activation
Sign Up to like & getrecommendations! Published in 2019 at "ACS Catalysis"
DOI: 10.1021/acscatal.9b01233
Abstract: The unsaturated hydride complex RhClH{κ2-N,C-(C11H8N)}(IPr) {IPr = 1,3-bis-(2,6-diisopropylphenyl)imidazolin-2-carbene} (2) has been prepared via C–H activation of 2-phenylpyridine and fully characterized by spectroscopic methods and X-ray diffraction analysis. Complex 2 efficiently catalyzes the isomerization of terminal… read more here.
Keywords: hydride; alkylation alkenylation; tandem alkylation; alkylation ... See more keywords
Mesoporous Carbon-Supported Pd Nanoparticles in the Metallic State-Catalyzed Acylation of Amides with Aryl Esters via C–O Activation
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.1c07342
Abstract: Carbon, an abundant, inexpensive, and nonmetallic material, is an inimitable support in heterogeneous catalysis, and variable carbonaceous materials have been utilized to support metal nanoparticle catalysts. We developed an efficient and stable heterogeneous catalyst with… read more here.
Keywords: carbon; aryl esters; via activation; metallic state ... See more keywords
c-Jun N-terminal kinase promotes stem cell phenotype in triple-negative breast cancer through upregulation of Notch1 via activation of c-Jun
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.417
Abstract: c-Jun N-terminal kinase (JNK) plays a vital role in malignant transformation of different cancers, and JNK is highly activated in basal-like triple-negative breast cancer (TNBC). However, the roles of JNK in regulating cancer stem-like cell… read more here.
Keywords: phenotype; jnk; jun; tnbc ... See more keywords
Synthesis of largely π-extended naphthalenediimides via C–H activation towards highly soluble and narrow band-gap organic optoelectronic materials
Sign Up to like & getrecommendations! Published in 2017 at "Organic chemistry frontiers"
DOI: 10.1039/c7qo00061h
Abstract: Atom-economic coupling reactions based on C–H activation are generally used to synthesize small conjugated systems, but their applications in constructing largely π-conjugated systems have been rarely reported. Herein, we report the preparation of largely π-extended… read more here.
Keywords: synthesis largely; extended naphthalenediimides; largely extended; naphthalenediimides via ... See more keywords
Rh-Catalyzed C–C/C–N bond formation via C–H activation: synthesis of 2H-indazol-2-yl-benzo[a]carbazoles
Sign Up to like & getrecommendations! Published in 2019 at "Organic Chemistry Frontiers"
DOI: 10.1039/c9qo01120j
Abstract: Rh-Catalyzed site-selective C–H activation and ring opening/cyclization of 7-azabenzonorbornadienes with aryl-2H-indazoles is developed to furnish indazolyl-benzocarbazole frameworks. Substrate scope and mechanistic studies are important practical features. read more here.
Keywords: formation via; bond formation; activation synthesis; catalyzed bond ... See more keywords
Site-selective arylations of nature-inspired flavonoids or steroidal phenols via C—H or O—H activation
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2025.2530615
Abstract: Abstract Phenols are important structural elements of natural products and pharmaceuticals. Due to their versatile chemical transformability, phenols are frequently used building blocks in medicinal chemistry. Their aromatic nature allows directed C(sp2)—H functionalisations, especially at… read more here.
Keywords: chemistry; nature inspired; via activation; site selective ... See more keywords