Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
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DOI: 10.1038/nature25986
Abstract: The endogenous metabolite itaconate has recently emerged as a regulator of macrophage function, but its precise mechanism of action remains poorly understood. Here we show that itaconate is required for the activation of the anti-inflammatory… read more here.
Keywords: anti inflammatory; itaconate anti; itaconate; via alkylation ... See more keywords