Apoptotic extracellular vesicles alleviate Pg-LPS induced inflammation of macrophages via AMPK/SIRT1/NF-κB pathway and inhibit adjacent osteoclasts formation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of periodontology"
DOI: 10.1002/jper.21-0657
Abstract: BACKGROUND Periodontitis is caused by the imbalance of anti-bacteria immune response and excessive inflammation whereas macrophages play an important role in inflammation. Thus, it is critical for finding efficient anti-inflammatory strategies to alleviate periodontal inflammation… read more here.
Keywords: inflammation; sirt1 pathway; ampk sirt1; osteoclasts formation ... See more keywords
6'-O-acetyl mangiferin from Iris rossii Baker inhibits lipid accumulation partly via AMPK activation in adipogenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.108755
Abstract: Effective control of white adipose tissue accumulation would provide a therapeutic strategy for obesity, which poses a growing global problem. The plant chemical mangiferin stimulates adenosine monophosphate-activated protein kinase (AMPK), which inhibits adipogenesis and has… read more here.
Keywords: accumulation; acetyl mangiferin; lipid accumulation; via ampk ... See more keywords
The adipokine orosomucoid alleviates adipose tissue fibrosis via the AMPK pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Acta pharmacologica Sinica"
DOI: 10.1038/s41401-021-00666-9
Abstract: The excess deposition of underlying extracellular matrix (ECM) in adipose tissue is defined as adipose tissue fibrosis that is a major contributor to metabolic disorder such as obesity and type 2 diabetes. Anti-fibrosis therapy has… read more here.
Keywords: adipokine orosomucoid; via ampk; tissue; adipose tissue ... See more keywords
Emodin in Rheum undulatum inhibits oxidative stress in the liver via AMPK with Hippo/Yap signalling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2020.1750658
Abstract: Abstract Context Emodin is a compound in Rheum undulatum Linne (Polygonaceae) that has been reported to exert anti-inflammatory, antibacterial, and antiallergic effects. Objective Oxidative stress is a causative agent of liver inflammation that may lead… read more here.
Keywords: inhibits oxidative; oxidative stress; via ampk; signalling pathway ... See more keywords
NANOG regulates epithelial–mesenchymal transition via AMPK/mTOR signalling pathway in ovarian cancer SKOV‐3 and A2780 cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17557
Abstract: NANOG engages with tumour initiation and metastasis by regulating the epithelial–mesenchymal transition (EMT) in epithelial ovarian cancer (EOC). However, its role in association with pAMPKα, and its clinical significance in EOC have not been elucidated… read more here.
Keywords: mesenchymal transition; ovarian cancer; ampk mtor; epithelial mesenchymal ... See more keywords
Exogenous H2S Protects Against Diabetic Cardiomyopathy by Activating Autophagy via the AMPK/mTOR Pathway
Sign Up to like & getrecommendations! Published in 2017 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000481758
Abstract: Background/Aim: Autophagy plays an important role in cellular homeostasis through the disposal and recycling of cellular components. Hydrogen sulphide (H2S) is the third endogenous gas that has been shown to confer cardiac protective effects. Given… read more here.
Keywords: mtor pathway; via ampk; ampk mtor; mtor ... See more keywords
Methionine Restriction Diet Improves Metabolic Function in Obese C57BL/6 Female Mice via AMPK/SIRT1/PGC1α Pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Food and Nutrition Research"
DOI: 10.12691/jfnr-7-2-1
Abstract: Methionine restriction has been proven to reverse age and obesity related metabolic diseases. Basically, MR regulates energy homeostasis in the whole body contributing to enhanced insulin sensitivity and improved redox status. There is no studies… read more here.
Keywords: methionine; via ampk; ampk sirt1; methionine restriction ... See more keywords
Propofol inhibits the malignant development of osteosarcoma U2OS cells via AMPK/FΟΧO1-mediated autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Oncology Letters"
DOI: 10.3892/ol.2022.13430
Abstract: It has previously been reported that propofol regulates the development of human osteosarcoma (OS). However, the specific molecular mechanisms underlying the effect of propofol on OS remain poorly understood. Therefore, the aim of the present… read more here.
Keywords: cell; development; propofol; via ampk ... See more keywords