Cadherins can dimerize via asymmetric interactions
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DOI: 10.1002/1873-3468.14373
Abstract: Cadherins are essential cell–cell adhesion proteins that interact in two distinct conformations: X‐dimers and strand‐swap dimers. Both X‐dimers and strand‐swap dimers are thought to exclusively rely on symmetric sets of interactions between key amino acids… read more here.
Keywords: cadherins dimerize; cadherin binding; via asymmetric; swap dimers ... See more keywords
A Pd-catalyzed asymmetric allylic substitution cascade via an asymmetric desymmetrization for the synthesis of bicyclic dihydrofurans.
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DOI: 10.1039/c9cc07204g
Abstract: A Pd-catalyzed asymmetric allylic substitution cascade of allylic meso-dicarbonates with 3-oxo-nitriles has been developed for the synthesis of chiral bicyclic dihydrofurans bearing two vicinal carbon stereocenters. The reaction proceeds via an asymmetric desymmetrization process with… read more here.
Keywords: catalyzed asymmetric; asymmetric allylic; bicyclic dihydrofurans; allylic substitution ... See more keywords
Kinetic resolution of N-aryl β-amino alcohols via asymmetric aminations of anilines.
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DOI: 10.1039/d1cc03117a
Abstract: An efficient kinetic resolution of N-aryl β-amino alcohols has been developed via asymmetric para-aminations of anilines with azodicarboxylates enabled by chiral phosphoric acid catalysis. Broad substrate scope and high kinetic resolution performances were afforded with… read more here.
Keywords: resolution; aryl amino; kinetic resolution; resolution aryl ... See more keywords