Expanding the scope of native chemical ligation – templated small molecule drug synthesis via benzanilide formation
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DOI: 10.1039/d1sc00513h
Abstract: We describe a reaction system that enables the synthesis of Bcr–Abl tyrosine kinase inhibitors (TKI) via benzanilide formation in water. The reaction is based on native chemical ligation (NCL). In contrast to previous applications, we… read more here.
Keywords: native chemical; via benzanilide; formation; chemical ligation ... See more keywords