Zinc‐Catalysed [3+2] Cycloaddition of Enaminone with Tosylhydrazide to Synthesise 1H‐pyrazole via C–N and S–N Bond Cleavage
Sign Up to like & getrecommendations! Published in 2024 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.202400549
Abstract: A novel and practical zinc‐catalysed synthesis of 1H‐pyrazole has been developed. The one‐pot protocol enables the cycloaddition of enaminone and tosylhydrazide via C–N and S–N bond breaking process, leading to diverse mono‐substituted pyrazole derivatives in… read more here.
Keywords: enaminone tosylhydrazide; via bond; cycloaddition enaminone; zinc catalysed ... See more keywords
Nickel-Catalyzed Csp2-Csp3 Bond Formation via C-F Bond Activation.
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DOI: 10.1021/acs.orglett.8b02351
Abstract: A nickel-catalyzed cross coupling of aryl fluorides via C-F bond activation has been developed. The alkylation method allows selective replacement of aryl fluorides by alkyl groups and enables the synthesis of diverse and otherwise difficult… read more here.
Keywords: bond; bond activation; via bond; catalyzed csp2 ... See more keywords
Ag(I)-Catalyzed [3 + 2]-Annulation of Cyclopropenones and Formamides via C-C Bond Cleavage.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b02612
Abstract: An unprecedented Ag-catalyzed [3 + 2]-annulation of cyclopropenones and DMF via C-C bond cleavage is disclosed. This protocol exhibited excellent chemo- and regio-selectivity, and tolerated various functional groups. More importantly, DMF served as the C═O… read more here.
Keywords: bond; bond cleavage; via bond; annulation cyclopropenones ... See more keywords
Asymmetric Allylic Alkylation of β-Ketoesters via C–N Bond Cleavage of N-Allyl-N-methylaniline Derivatives Catalyzed by a Nickel–Diphosphine System
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DOI: 10.1021/acscatal.0c01356
Abstract: Nickel complexes bearing chiral diphosphine ligands, such as (S)-Tol-MeO-BIPHEP and (S)-H8-BINAP, serve as efficient catalysts for asymmetric allylic alkylation (AAA) of β-ketoesters, using allylic... read more here.
Keywords: allylic alkylation; alkylation ketoesters; asymmetric allylic; via bond ... See more keywords
Alkyl Radical Generation via C–C Bond Cleavage in 2-Substituted Oxazolidines
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DOI: 10.1021/acscatal.2c03768
Abstract: There is an urgent need to develop uncharged radical precursors to be activated under mild photocatalyzed conditions. 2-Substituted-1,3-oxazolidines (Eox < 1.3 V vs SCE, smoothly prepared from the corresponding aldehydes) have been herein employed for… read more here.
Keywords: alkyl radical; cleavage; substituted oxazolidines; via bond ... See more keywords
Electrosynthesis of Nitriles from Nitrate and Aldehyde via C≡N Bond Construction.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.5c09570
Abstract: Electrocatalytic nitrate reduction offers a promising approach to synthesizing valuable organic nitrogen compounds via C-N coupling, serving as a pivotal solution to the pressing nitrate pollution issue. While significant progress has been made in electrosynthesizing… read more here.
Keywords: nitriles nitrate; electrosynthesis nitriles; via bond; aldehyde via ... See more keywords
Harnessing Alkyl Amines as Electrophiles for Nickel-Catalyzed Cross Couplings via C-N Bond Activation.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b02389
Abstract: We developed a strategy to harness alkyl amines as alkylating agents via C-N bond activation. This Suzuki-Miyaura cross coupling of alkylpyridinium salts, readily formed from primary amines, is the first example of a metal-catalyzed cross… read more here.
Keywords: catalyzed cross; bond activation; alkyl amines; via bond ... See more keywords
Magnesium-mediated arylation of amines via C-F bond activation of fluoroarenes.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc01670h
Abstract: A series of new Mg(ii) amides featuring a bulky β-diketiminate backstop ligand, has been synthesised. These complexes are demonstrated to be excellent sources of nucleophilic amides that can participate in rapid C-F activation of several… read more here.
Keywords: arylation amines; amines via; mediated arylation; activation ... See more keywords
Developments towards synthesis of N-heterocycles from amidines via C–N/C–C bond formation
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DOI: 10.1039/c9qo00283a
Abstract: This review focuses on the synthesis of N-heterocycles using amidines as starting materials, with an emphasis on the mechanisms of these reactions via C–N/C–C bond formation. read more here.
Keywords: synthesis heterocycles; via bond; bond formation;
Microwave-assisted copper(i) catalyzed A3 cascade coupling of imidazo[1,2-a]pyridines via C–H bond functionalization as selective COX-2 inhibitors and antioxidants, and in silico studies
Sign Up to like & getrecommendations! Published in 2023 at "New Journal of Chemistry"
DOI: 10.1039/d3nj00524k
Abstract: A proficient copper(i) catalyzed one pot synthetic protocol has been established to synthesize medicinally essential substituted imidazo[1,2-a]pyridines via C–H bond amination followed by acetylene incorporation under microwave irradiation. read more here.
Keywords: imidazo pyridines; copper catalyzed; pyridines via; via bond ... See more keywords
Rh(III)-catalyzed aldehydic and aryl C-H alkylation with cyclopropanols via C-H/C-C bond activation.
Sign Up to like & getrecommendations! Published in 2024 at "Chemical communications"
DOI: 10.1039/d4cc03797a
Abstract: Herein, we report Rh(III) catalyzed aldehydic or aryl C-H alkylation via C-C bond activation of cyclopropanols, facilitating the synthesis of β-functionalized ketones. The protocol employs cyclopropanol as the alkylating agent with 2-aminobenzaldehyde or aniline derivatives… read more here.
Keywords: bond activation; aryl alkylation; via bond; aldehydic aryl ... See more keywords