Diphosphine Bioconjugates via Pt(0)-Catalyzed Hydrophosphination. A Versatile Chelator Platform for Technetium-99m and Rhenium-188 Radiolabeling of Biomolecules.
Sign Up to like & getrecommendations! Published in 2023 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.2c04008
Abstract: The ability to append targeting biomolecules to chelators that efficiently coordinate to the diagnostic imaging radionuclide, 99mTc, and the therapeutic radionuclide, 188Re, can potentially enable receptor-targeted "theranostic" treatment of disease. Here we show that Pt(0)-catalyzed… read more here.
Keywords: bioconjugates via; chelator; hydrophosphination; catalyzed hydrophosphination ... See more keywords
Synthesis of Ladder-Type 9,9'-Bifluorenylidene-Based Conjugated Oligomers via a Pd-Catalyzed Tandem Suzuki Coupling/Heck Cyclization Approach.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02418
Abstract: For new ladder-type oligomers and polymers with versatile and robust synthetic strategies, in this study, four fully conjugated ladder-type overcrowded 9,9'-bifluorenylidene-based compounds and oligomers (BFY1, BFY2, BFY3, and BFY4) were synthesized via a Pd-catalyzed tandem… read more here.
Keywords: bifluorenylidene based; spectroscopy; via catalyzed; ladder ... See more keywords
Route to Chiral Tetrahydrofuran Acetals via Pd-Catalyzed Asymmetric Allylic Cycloaddition of Vinyl Epoxides with β-Keto Enol Ethers.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02437
Abstract: An efficient method for the synthesis of functionalized chiral tetrahydrofuran (THF) acetals via Pd-catalyzed asymmetric allylic cycloaddition has been developed. With a palladium catalyst coordinated by a chiral phosphine ligand, the protocol is enabled to… read more here.
Keywords: allylic cycloaddition; via catalyzed; acetals via; catalyzed asymmetric ... See more keywords
Synthesis of 1,1,4,5-Tetrasubstituted Phthalans via Pd-Catalyzed Three-Component Reactions of Haloarenes, Alkynes, and Protic Nucleophiles.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03460
Abstract: A novel approach for the synthesis of 1,1,4,5-tetrasubstituted phthalans is developed via a tandem palladium-catalyzed Sonogashira coupling/propargyl-allenyl isomerization/pentadehydro-Diels-Alder cyclization/regioselective nucleophilic addition sequence. The reaction shows good functional tolerance and provides a wide variety of substituted… read more here.
Keywords: phthalans via; tetrasubstituted phthalans; synthesis tetrasubstituted; via catalyzed ... See more keywords
Synthesis of 2-Cyanomethyl Indane Derivatives via Pd-Catalyzed Alkene Difunctionalization Reactions of Alkyl Nitriles.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00571
Abstract: The synthesis of indanes bearing substituted cyanomethyl groups at C2 is achieved through Pd-catalyzed coupling reactions between 2-allylphenyl triflate derivatives and alkyl nitriles. Related partially saturated analogues were generated from analogous transformations of alkenyl triflates.… read more here.
Keywords: cyanomethyl indane; alkyl nitriles; synthesis cyanomethyl; via catalyzed ... See more keywords
Synthesis of Biindene Derivatives via Pd-Catalyzed Alkene Difunctionalization Reactions.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c01400
Abstract: The palladium-catalyzed cross-coupling of 2-allylphenyl triflate and related electrophiles with substituted indenes affords biindene derivatives in moderate to good yields with high selectivity for thermodynamically preferred alkene isomers. The transformations involve alkene nucleopalladation with indenyl… read more here.
Keywords: via catalyzed; catalyzed alkene; alkene difunctionalization; synthesis biindene ... See more keywords
Asymmetric Multi-Atom Insertion of Esters via Rh-Catalyzed Ring Opening of Oxabicyclic Alkenes.
Sign Up to like & getrecommendations! Published in 2025 at "Organic letters"
DOI: 10.1021/acs.orglett.5c00971
Abstract: Precise skeletal manipulation involving insertion, deletion, and replacement has garnered considerable attention within the synthetic chemistry community. Among these processes, multi-atom insertion reactions in acyclic compounds remain a formidable challenge, primarily due to the low… read more here.
Keywords: multi atom; via catalyzed; asymmetric multi; insertion ... See more keywords
Unified Approach to Substituted Allenoates via Pd-Catalyzed β-Hydride Elimination of (E)-Enol Triflates.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b02736
Abstract: A robust synthesis of allenoates via a Pd-catalyzed β-hydride elimination of (E)-enol triflates is presented. Salient features of this method include low catalyst loadings, mild reaction conditions, and the ability to access all four patterns… read more here.
Keywords: catalyzed hydride; hydride elimination; enol triflates; via catalyzed ... See more keywords
Regio- and Diastereoselective Access to Fused Isoxazolidines via Ru(II)-Catalyzed C-H Activation of Nitrones and Coupling with Perfluoroalkylolefins.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.7b03775
Abstract: The synthsis of fluorinated isoxazolidines in bicyclic settings has been realized via Ru(II)-catalyzed C-H activation of aryl nitrones with perfluoroalkyl-substituted olefins as the coupling partner. The reaction proceeded via initial chelation-assisted C(aryl)-H allylation followed by… read more here.
Keywords: diastereoselective access; via catalyzed; regio diastereoselective; catalyzed activation ... See more keywords
Syntheses of Unsymmetrical 1,4-Bifunctional Allylboron Reagents via Cu-catalyzed Highly Regio- and Stereoselective 1,4-Protoboration of Dienylboronates and Analysis of the Origin of Chemoselective Aldehyde syn-(Hydroxymethyl)allylation.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b03483
Abstract: The syntheses of unsymmetrical 1,4-bifunctional allylboron reagents via Cu-catalyzed highly regio- and stereoselective 1,4-protoboration of dienylboronates were developed. The resulting allylboronates underwent chemoselective allylboration with aldehydes followed by oxidative workup to give diol products with… read more here.
Keywords: bifunctional allylboron; reagents via; unsymmetrical bifunctional; via catalyzed ... See more keywords
Enantioselective Synthesis of Atropisomeric Anilides via Pd(II)-Catalyzed Asymmetric C-H Olefination.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c09400
Abstract: Atropisomeric anilides have received tremendous attention as a novel class of chiral compounds possessing restricted rotation around an N-aryl chiral axis. However, in sharp contrast to the well-studied synthesis of biaryl atropisomers, the catalytic asymmetric… read more here.
Keywords: catalyzed asymmetric; via catalyzed; atropisomeric anilides; synthesis atropisomeric ... See more keywords