C-H Functionalization of Peptides via Cyclic Aminal Intermediates.
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DOI: 10.1021/acs.orglett.1c02041
Abstract: Protected dipeptides can be converted into cyclic ketoaminals, which can be subjected to palladium-catalyzed regioselective C-H functionalization. The best results are obtained using the 2-(methylthio)aniline (MTA) directing group, which is superior to the commonly used… read more here.
Keywords: peptides via; via cyclic; aminal intermediates; cyclic aminal ... See more keywords