Versatile Diazomethane Sulfonamide for Expedited Exploration of Azole‐Based Carbonic Anhydrase Inhibitors via [3+2] Cycloaddition
Sign Up to like & getrecommendations! Published in 2023 at "ChemMedChem"
DOI: 10.1002/cmdc.202200607
Abstract: A newly introduced diazo reagent, 1‐diazo‐N,N‐bis(4‐methoxybenzyl)methanesulfonamide, enables access to a range of azole‐based primary sulfonamides via [3+2] cycloaddition followed by protecting group removal. Such compounds are representative of the sulfonamide chemical space highly relevant but… read more here.
Keywords: azole based; via cycloaddition; carbonic anhydrase;
The synthesis of isoxazolo[2,3-c]quinazolines via a cycloaddition of quinazoline-3-oxides and acrylates
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2020.151818
Abstract: Abstract A variety of isoxazolo[2,3-c]quinazolines were synthesized via a [3 + 2] cycloaddition of quinazoline-3-oxides with acrylates. The reaction exhibits a broad substrate scope and good functional group tolerance. The corresponding isoxazolo[2,3-c]quinazolines can be obtained in good… read more here.
Keywords: oxides acrylates; quinazoline oxides; cycloaddition quinazoline; via cycloaddition ... See more keywords
A new access to diazaphospholes via cycloaddition-cycloreversion reactions on triazaphospholes.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc02269a
Abstract: A novel bis-CF3-substituted diazaphosphole was synthesized selectively from hexafluoro-2-butyne and a 3H-1,2,3,4-triazaphosphole derivative. The [4+2] cycloaddition and subsequent cycloreversion reaction under elimination of pivaloyl nitrile affords the product in high yield. The heterocycle coordinates via… read more here.
Keywords: cycloreversion; diazaphospholes via; via cycloaddition; new access ... See more keywords
Regioselective Synthesis of 5-Trifluoromethyl 1,2,4-Triazoles via [3 + 2]-Cycloaddition of Nitrile Imines with CF3CN
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27196568
Abstract: We herein describe a general approach to 5-trifluoromethyl 1,2,4-triazoles via the [3 + 2]-cycloaddition of nitrile imines generated in situ from hydrazonyl chloride with CF3CN, utilizing 2,2,2-trifluoroacetaldehyde O-(aryl)oxime as the precursor of trifluoroacetonitrile. Various functional… read more here.
Keywords: triazoles via; via cycloaddition; trifluoromethyl triazoles; cycloaddition nitrile ... See more keywords