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Chiral piperidines from acyclic amines via enantioselective, radical-mediated δ C-H cyanation.

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0 Published in 2019 at "Chem"

DOI: 10.1016/j.chempr.2019.09.010

Abstract: Piperidines are the most prevalent heterocycle found in medicines. Yet, while they are often chiral, there remain no robust methods for their asymmetric syntheses. To solve this challenge, we have interrupted the century-old Hofmann-Löffler-Freytag (HLF)… read more here.

Keywords: piperidines acyclic; chiral piperidines; amines via; cyanation ... See more keywords

Atroposelective Synthesis of N-Arylindoles via Enantioselective N-H Bond Insertion.

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1 Published in 2022 at "Organic letters"

DOI: 10.1021/acs.orglett.2c03003

Abstract: We present here a rhodium-catalyzed asymmetric N-H insertion reaction, which is a concerted process revealed by DFT calculations, for the synthesis of novel axially chiral N-arylindoles by the reaction between indoles and diazonaphthoquinones. The reaction… read more here.

Keywords: synthesis arylindoles; synthesis; insertion; arylindoles via ... See more keywords

Synthesis of (+)-Disparlure via Enantioselective Iodolactonization.

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0 Published in 2018 at "Organic letters"

DOI: 10.1021/acs.orglett.7b03911

Abstract: The BINOL-amidine organic catalyst 1 was previously shown to promote highly efficient enantioselective halolactonization reactions of olefinic acids. As part of these studies, it was discovered that the enantioenriched iodolactones could be easily converted into… read more here.

Keywords: synthesis disparlure; disparlure via; disparlure; via enantioselective ... See more keywords

Synthesis of fluorocyclopropanes via the enantioselective cyclopropanation of fluoro-substituted allylic alcohols using zinc carbenoids

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0 Published in 2020 at "Canadian Journal of Chemistry"

DOI: 10.1139/cjc-2020-0036

Abstract: Cyclopropanation reactions using zinc carbenoids are a powerful means to access cyclopropanes. Described herein is an enantioselective version of the reaction using zinc reagents and a chiral dioxa... read more here.

Keywords: cyclopropanation; zinc carbenoids; using zinc; fluorocyclopropanes via ... See more keywords

The Synthesis of α-Aminophosphonates via Enantioselective Organocatalytic Reaction of 1-(N-Acylamino)alkylphosphonium Salts with Dimethyl Phosphite

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0 Published in 2020 at "Molecules"

DOI: 10.3390/molecules25020405

Abstract: α-Aminophosphonic acids are phosphorus analogues of α-amino acids. Compounds of this type find numerous applications in medicine and crop protection due to their unique biological activities. A crucial factor in these activities is the configuration… read more here.

Keywords: amino acids; acylamino; synthesis aminophosphonates; via enantioselective ... See more keywords