Enhancement of rAAV titers via inhibition of the interferon signaling cascade in transfected HEK293 suspension cultures
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology Journal"
DOI: 10.1002/biot.202300672
Abstract: The production of recombinant adeno‐associated virus (rAAV) for gene therapy applications relies on the use of various host cell lines, with suspension‐grown HEK293 cells being the preferred expression system due to their satisfactory rAAV yields… read more here.
Keywords: enhancement raav; inhibition interferon; via inhibition; titers via ... See more keywords
3025 – AZACITIDINE INDUCES THROMBOCYTOPENIA VIA INHIBITION OF MEGAKARYOPOIESIS
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2020.09.045
Abstract: Thrombocytopenia defined as platelet counts of Several studies evaluating the use of thrombopoietin receptor agonists (TPO-RA) for the clinical management of thrombocytopenia have shown promising clinical results. TPO-RA eltrombopag (EP) which has been effective as… read more here.
Keywords: via inhibition; induces thrombocytopenia; azacitidine induces; thrombocytopenia via ... See more keywords
Eicosapentaenoic acid ameliorates pulmonary hypertension via inhibition of tyrosine kinase Fyn.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2020.08.013
Abstract: Pulmonary arterial hypertension (PAH) is a multifactorial disease characterized by pulmonary arterial vasoconstriction and remodeling. Src family tyrosine kinases, including Fyn, play critical roles in vascular remodeling via the inhibition of STAT3 signaling. EPA is… read more here.
Keywords: via inhibition; src family; epa rve1; hypertension ... See more keywords
Alleviation of hepatic fibrosis and autophagy via inhibition of transforming growth factor‐β1/Smads pathway through shikonin
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.14299
Abstract: Liver fibrosis is a worldwide clinical challenge during the progression of chronic liver disease to liver cirrhosis. Shikonin is extracted from the root of Lithospermum erythrorhizon with antioxidant, anti‐inflammatory, anticancer, and wound‐healing properties. The study… read more here.
Keywords: alleviation hepatic; fibrosis; via inhibition; autophagy via ... See more keywords
Botulinum Toxin Type A Alleviates Benign Prostatic Hyperplasia by Regulating Progression of Epithelial-Mesenchymal Transition via Inhibition of Hypoxia-Inducible Factor-1α
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Biomedical Nanotechnology"
DOI: 10.1166/jbn.2023.3496
Abstract: This study proposes to explore the impact of BTX-A on BPD and the functional mechanism. In this study, RWPE-1 cells were stimulated with 10 ng/mL DHT, followed by treatment with 5, 10, and 20 U/mL… read more here.
Keywords: rwpe cells; regulating progression; btx; progression ... See more keywords
Avapritinib Carries the Risk of Drug Interaction via Inhibition of UDP-Glucuronosyltransferase (UGT) 1A1.
Sign Up to like & getrecommendations! Published in 2024 at "Current drug metabolism"
DOI: 10.2174/0113892002288312240521092054
Abstract: BACKGROUND Avapritinib is the only drug for adult patients with PDGFRA exon 18 mutated unresectable or metastatic Gastrointestinal Stromal Tumor (GIST). Although avapritinib has been approved by the FDA for three years, little is known… read more here.
Keywords: risk drug; inhibition; avapritinib carries; via inhibition ... See more keywords
Polyalthia Clerodane Diterpene Potentiates Hypoglycemia via Inhibition of Dipeptidyl Peptidase 4
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20030530
Abstract: Serine protease dipeptidyl peptidase 4 (DPP-4) is involved in self/non-self-recognition and insulin sensitivity. DPP-4 inhibitors are conventional choices for diabetic treatment; however, side effects such as headache, bronchus infection, and nasopharyngitis might affect the daily… read more here.
Keywords: dipeptidyl peptidase; inhibition; via inhibition; clerodane diterpene ... See more keywords
Punicalagin Ameliorates Lupus Nephritis via Inhibition of PAR2
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21144975
Abstract: Lupus nephritis (LN) is the most frequent phenotype in patients with systemic lupus erythematosus (SLE) and has a high rate of progression to end-stage renal disease, in spite of intensive treatment and maintenance therapies. Recent… read more here.
Keywords: par2; pcg; inhibition par2; via inhibition ... See more keywords
Synthetic chalcone derivatives inhibit cytokine secretion via inhibition of ERK and JNK pathways in human U937 macrophage
Sign Up to like & getrecommendations! Published in 2021 at "Tropical Journal of Pharmaceutical Research"
DOI: 10.4314/tjpr.v18i4.11
Abstract: Purpose: To investigate the inhibitory effects of a chalcone derivative on lipopolysaccharide (LPS)induced interleukin (IL)-6 and IL-8 secretions and on LPS-induced mitogen-activated protein kinases (MAPK) and nuclear factor kappa B (NF-κB) activation in human U937… read more here.
Keywords: via inhibition; secretion; inhibition erk; u937 macrophage ... See more keywords