Synthesis of 3-SCF2H-/3-SCF3-chromones via Interrupted Pummerer Reaction/Intramolecular Cyclization Mediated by Difluoromethyl or Trifluoromethyl Sulfoxide and Tf2O.
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DOI: 10.1021/acs.orglett.2c03017
Abstract: The reaction of alkynyl aryl ketones bearing an o-methoxy group with difluoromethyl sulfoxide in the presence of Tf2O was found to conveniently afford the corresponding 3-SCF2H-substituted chromones. The combining use of difluoromethyl sulfoxide/Tf2O could represent… read more here.
Keywords: reaction; sulfoxide tf2o; via interrupted; sulfoxide ... See more keywords
Catalytic α-Hydroarylation of Acrylates and Acrylamides via an Interrupted Hydrodehalogenation Reaction.
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DOI: 10.1021/jacs.0c03040
Abstract: The palladium-catalyzed, α-selective hydroarylation of acrylates and acrylamides is reported. Under optimized conditions, this method is highly tolerant of a wide range of substrates including those with base sensitive functional groups and/or multiple enolizable carbonyl… read more here.
Keywords: acrylates acrylamides; acrylamides via; via interrupted; hydroarylation acrylates ... See more keywords