Human electronegative low-density lipoprotein modulates cardiac repolarization via LOX-1-mediated alteration of sarcolemmal ion channels
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-10503-x
Abstract: Dyslipidemia is associated with greater risk of ventricular tachyarrhythmias in patients with cardiovascular diseases. We aimed to examine whether the most electronegative subfraction of low-density lipoprotein (LDL), L5, is correlated with QTc prolongation in patients… read more here.
Keywords: cardiac repolarization; via lox; density lipoprotein; lox ... See more keywords
OxLDL increases brain and aortic VSM inflammation and contributes to vascular dysregulation and altered vasoreactivity via the LOX-1 receptor
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5735310
Abstract: Elevation in circulating levels of oxidized low-density lipoprotein (oxLDL) and vascular inflammation are significant risk factors for the pathogenesis of vascular diseases, such as atherosclerosis and stroke. OxLDL, via the lectin-like oxLDL receptor 1 (LOX-1),… read more here.
Keywords: inflammation; vasoreactivity; via lox; physiology ... See more keywords