Anti-inflammatory effects of an optimized PPAR-γ agonist via NF-κB pathway inhibition.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103611
Abstract: In our previous study, a PPAR-γ agonist (+)-(R,E)-6a1 was elaborated as an anti-inflammatory lead. However, in silico analysis showed that (+)-(R,E)-6a1 lacks key hydrogen bonding with Tyr473 of PPAR-γ LBD (ligand binding domain). To facilitate… read more here.
Keywords: anti inflammatory; pathway inhibition; inhibition; via pathway ... See more keywords
Biosynthesis of Tasikamides via Pathway Coupling and Diazonium-Mediated Hydrazone Formation.
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DOI: 10.1021/jacs.1c10369
Abstract: Naturally occurring hydrazones are rare despite the ubiquitous usage of synthetic hydrazones in the preparation of organic compounds and functional materials. In this study, we discovered a family of novel microbial metabolites (tasikamides) that share… read more here.
Keywords: biosynthesis; biosynthesis tasikamides; tasikamides via; diazonium ... See more keywords
Synovial Fluid Regulates the Gene Expression of a Pattern of microRNA via the NF-κB Pathway: An In Vitro Study on Human Osteoarthritic Chondrocytes
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158334
Abstract: Synovial fluid (SF) represents the primary source of nutrients of articular cartilage and is implicated in maintaining cartilage metabolism. We investigated the effects of SF, from patients with osteoarthritis (OA), rheumatoid arthritis (RA), and controls,… read more here.
Keywords: pattern microrna; expression; gene expression; synovial fluid ... See more keywords