Design and Development of Novel Glitazones for Activation of PGC-1α Signaling Via PPAR-γ Agonism: A Promising Therapeutic Approach against Parkinson’s Disease
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DOI: 10.1021/acsomega.2c07521
Abstract: Herein, we rationally designed and developed two novel glitazones (G1 and G2) to target peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α) signaling through peroxisome proliferator-activated receptors (PPAR)-γ agonism as a therapeutic for Parkinson’s disease (PD). The… read more here.
Keywords: via ppar; ppar agonism; pgc signaling; parkinson disease ... See more keywords