Evodiamine Inhibits Lipopolysaccharide (LPS)-Induced Inflammation in BV-2 Cells via Regulating AKT/Nrf2-HO-1/NF-κB Signaling Axis
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-020-00839-w
Abstract: Neuroinflammation is caused by excessive activation of microglia and plays an essential role in neurodegenerative diseases. After activation, microglia produce several kinds of inflammatory mediators, trigger an excessive inflammatory response, and ultimately destroy the surrounding… read more here.
Keywords: lps induced; via regulating; neuroinflammation; lipopolysaccharide lps ... See more keywords
Geniposide suppresses thermogenesis via regulating PKA catalytic subunit in adipocytes.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology"
DOI: 10.1016/j.tox.2021.153014
Abstract: Geniposide has been widely found to ameliorate many metabolic diseases. The recruitment and activation of brown/beige adipocytes are effective and promising methods for counteracting obesity and related diseases. However, the effect of geniposide on thermogenesis… read more here.
Keywords: suppresses thermogenesis; catalytic subunit; via regulating; pka catalytic ... See more keywords
Laminaria japonica Polysaccharide Suppresses Atherosclerosis via Regulating Autophagy-Mediated Macrophage Polarization.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c07483
Abstract: The present work aimed to explore the effect and underlying mechanism of a homogeneous Laminaria japonica polysaccharide (LJP61A) on macrophage polarization in high-fat-diet-fed LDLr-/- mice and Ox-LDL-induced macrophages. Results showed that LJP61A remarkably reduced the… read more here.
Keywords: macrophage polarization; macrophage; via regulating; laminaria japonica ... See more keywords
Ganoderma lucidum extract ameliorates MPTP-induced parkinsonism and protects dopaminergic neurons from oxidative stress via regulating mitochondrial function, autophagy, and apoptosis
Sign Up to like & getrecommendations! Published in 2018 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-018-0077-8
Abstract: Neuroprotection targeting mitochondrial dysfunction has been proposed as an important therapeutic strategy for Parkinson’s disease. Ganoderma lucidum (GL) has emerged as a novel agent that protects neurons from oxidative stress. However, the detailed mechanisms underlying… read more here.
Keywords: gle; via regulating; neurons oxidative; parkinsonism ... See more keywords
SRPK1 promotes sepsis-induced acute lung injury via regulating PI3K/AKT/FOXO3 signaling
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2134789
Abstract: Abstract Objective Sepsis is the most common cause of death in the intensive care unit. Moreover, sepsis is the leading cause of acute lung injury (ALI). Serine-arginine protein kinase 1 (SRPK1) was demonstrated to promote… read more here.
Keywords: sepsis; acute lung; via regulating; induced ali ... See more keywords
Long non-coding RNA tumor protein 53 target gene 1 promotes cervical cancer development via regulating microRNA-33a-5p to target forkhead box K2
Sign Up to like & getrecommendations! Published in 2022 at "Cell Cycle"
DOI: 10.1080/15384101.2022.2026705
Abstract: ABSTRACT Long non-coding RNA tumor protein 53 target gene 1 (TP53TG1) has been unraveled to exert regulatory effects on cancer progression, while the regulatory function of TP53TG1 on cervical cancer (CC) via regulating microRNA (miR)-33a-5p/Forkhead… read more here.
Keywords: via regulating; mir 33a; tp53tg1; foxk2 ... See more keywords
Lentinan administration alleviates diarrhea of rotavirus-infected weaned pigs via regulating intestinal immunity
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Animal Science and Biotechnology"
DOI: 10.1186/s40104-021-00562-6
Abstract: Background Lentinan (LNT) may regulate many important physiological functions of human and animals. This study aimed to verify whether LNT administration could relieve diarrhea via improving gut immunity in rotavirus (RV)-challenged weaned pigs. Methods Twenty-eight… read more here.
Keywords: administration; immunity; via regulating; weaned pigs ... See more keywords
Genetic variations in UCA1, a lncRNA functioning as a miRNA sponge, determine endometriosis development and the potential associated infertility via regulating lipogenesis
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0271616
Abstract: Endometriosis is a hormone-associated disease which has been considered as the precursor for certain types of ovarian cancer. In recent years, emerging evidence demonstrated potent roles of lncRNA in regulating cancer development. Since endometriosis shares… read more here.
Keywords: via regulating; endometriosis; endometriosis development; genetic variations ... See more keywords
Melatonin inhibits the malignant progression of glioblastoma via regulating miR-16-5p/PIM1.
Sign Up to like & getrecommendations! Published in 2022 at "Current neurovascular research"
DOI: 10.2174/1567202619666220406084947
Abstract: OBJECTIVES Melatonin (MT) is a pineal hormone with antineoplastic potential. This study aims to explore the therapeutic potential and mechanism of MT on glioblastoma (GBM). METHODS A human GBM cell line, LN229 was used for… read more here.
Keywords: via regulating; mir pim1; malignant progression; inhibits malignant ... See more keywords