miR‐194 relieve neuropathic pain and prevent neuroinflammation via targeting FOXA1
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29598
Abstract: The emerging role of microRNAs (miRNAs) have been deeply explored in multiple diseases including neuropathic pain. miR‐194 was widely reported to be a tumor suppressor and was related to the inflammatory response. The critical role… read more here.
Keywords: 194 neuropathic; neuroinflammation; neuropathic pain; via targeting ... See more keywords
MiR-323a-3p suppressed the glycolysis of osteosarcoma via targeting LDHA
Sign Up to like & getrecommendations! Published in 2018 at "Human Cell"
DOI: 10.1007/s13577-018-0215-0
Abstract: Accumulating evidence has demonstrated that there is critical involvement of miRNAs in the initiation and progression of cancers. Here, we showed that miR-323a-3p was significantly down-regulated in osteosarcoma (OS) tissues and cell lines. Overexpression of… read more here.
Keywords: targeting ldha; glycolysis; mir 323a; osteosarcoma ... See more keywords
miR-145-5p is associated with smoke-related chronic obstructive pulmonary disease via targeting KLF5.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.01.011
Abstract: Increasing evidence illustrate that dysregulation of microRNAs (miRNAs) is involved in the pathogenesis of chronic obstructive pulmonary disease (COPD), which is mainly resulted from cigarette smoke (CS) exposure. However, the role of miR-145-5p in CS-mediated… read more here.
Keywords: chronic obstructive; mir 145; obstructive pulmonary; pulmonary disease ... See more keywords
Hyperoside ameliorates diabetic nephropathy induced by STZ via targeting the miR-499-5p/APC axis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2021.02.005
Abstract: Diabetic nephropathy is a serious complication of diabetes. Hyperoside has been widely reported to ameliorate diabetes-associated disease. The current study is designed to explore the mechanism of hyperoside in diabetic nephropathy. In the present study,… read more here.
Keywords: hyperoside ameliorates; apc; ameliorates diabetic; diabetic nephropathy ... See more keywords
Bta-miR-101 suppresses BEFV replication via targeting NKRF.
Sign Up to like & getrecommendations! Published in 2021 at "Veterinary microbiology"
DOI: 10.1016/j.vetmic.2021.109127
Abstract: MicroRNAs (miRNAs), as a kind of small noncoding RNAs, have been proved to play a regulatory role in virus infection. However, the role and mechanism of cellular miRNAs in bovine transient fever virus (BEFV) infection… read more here.
Keywords: via targeting; bta mir; mir 101; befv replication ... See more keywords
Upregulation of miR-132 contributes to the pathophysiology of COPD via targeting SOCS5.
Sign Up to like & getrecommendations! Published in 2018 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2018.10.002
Abstract: The role of microRNAs has been recently identified in chronic obstructive pulmonary disease (COPD). This study aimed to examine the role of miR-132 in the pathophysiology of COPD and to explore the underlying molecular mechanisms… read more here.
Keywords: mir 132; pathophysiology copd; expression; targeting socs5 ... See more keywords
MicroRNA-124 modulates neuroinflammation in acute methanol poisoning rats via targeting Krüppel-like factor-6
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2078549
Abstract: ABSTRACT Microglia activation-stimulated neuroinflammation exerts functionally in neurodegenerative diseases like brain injury. Acute methanol poisoning (AMP) is a crucial cause of death and morbidity that possibly leads to neuroinflammation. Studies have manifested that miRNAs can… read more here.
Keywords: mir 124; neuroinflammation; amp; acute methanol ... See more keywords
MiR-455-5p attenuates cerebral ischemic reperfusion injury via targeting FLT3.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000000898
Abstract: Cerebral ischemia-reperfusion (I/R) injury is a terrible disease which results in the dysfunction and structural damage of brain tissues. Growing evidence implies that miR-455-5p is implicated in the regulation of pathogenesis of several diseases. The… read more here.
Keywords: injury via; reperfusion injury; cerebral injury; mir 455 ... See more keywords
The Antibiotic Drug Trimethoprim Suppresses Tumor Growth and Metastasis via Targeting Snail.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of pharmacology"
DOI: 10.1111/bph.15763
Abstract: BACKGROUND AND PURPOSE The zinc finger transcription factor Snail is aberrantly activated in many human cancers and strongly associated with poor prognosis. As a transcription factor, Snail has been traditionally considered an "undruggable" target. Here,… read more here.
Keywords: targeting snail; via targeting; growth metastasis; tumor growth ... See more keywords
MiR-129-5p Inactivates NF-κB Pathway to Block Rheumatoid Arthritis Development via Targeting BRD4
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Healthcare Engineering"
DOI: 10.1155/2022/8330659
Abstract: Methods The abundance of miR-129-5p was detected in the samples including normal tissues and RA tissues and cell lines including human fibroblast-like synoviocytes (hFLSs) and human rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs). The CCK-8 assay, flow… read more here.
Keywords: targeting brd4; rheumatoid arthritis; mir 129; pathway block ... See more keywords
Natural occurring compounds inhibit osteoclastogenesis via targeting on NFATc1-related signaling pathways.
Sign Up to like & getrecommendations! Published in 2019 at "Current drug targets"
DOI: 10.2174/1389450120666191017121610
Abstract: Osteoclasts are originated from monocytic precursors of the hematopoietic lineage. Regulation of gene expression by transcription factors is one of the major mechanisms for controlling cellular functions. This is particularly important in the process of… read more here.
Keywords: occurring compounds; compounds inhibit; osteoclastogenesis via; natural occurring ... See more keywords