Cyclin dependent kinase 1 (CDK1) positively regulates cardiac hypertrophy and fibrosis via TGF-beta pathway
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DOI: 10.1093/ehjci/ehaa946.3743
Abstract: Transforming growth factor beta (TGF-β) critically mediates cardiac fibrosis by transforming fibroblasts to myofibroblasts in pathological conditions. Cyclin dependent kinases (CDKs), cell cycle-regulating proteins, are known to be intimately involved in cardiac fibrosis. Among CDK… read more here.
Keywords: cdk1; fibrosis; cardiac fibrosis; tgf ... See more keywords