Synthesis of Thiazoles and Isothiazoles via Three-Component Reaction of Enaminoesters, Sulfur, and Bromodifluoroacetamides/Esters.
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DOI: 10.1021/acs.orglett.0c01275
Abstract: A three-component strategy for the synthesis of thiazoles and isothiazoles has been developed by employing enaminoesters, fluorodibromoiamides/ester, and sulfur. The thiazoles and isothiazoles were formed via two C-F bond cleavages along with the formation of… read more here.
Keywords: synthesis thiazoles; thiazoles isothiazoles; via three; isothiazoles via ... See more keywords
Directed C3-Alkoxymethylation of Indole via Three-Component Cascade Reaction.
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DOI: 10.1021/acs.orglett.9b00357
Abstract: An efficient and regioselective C3-alkoxymethylation of indoles has been developed with aldehydes and alcohols via three-component cascade reaction under transition-metal free conditions. This method allows for rapid access to a variety of C3-alkoxymethylaed free (N-H)… read more here.
Keywords: via three; cascade reaction; three component; component cascade ... See more keywords
Facile synthesis of 1,4-diketones via three-component reactions of α-ketoaldehyde, 1,3-dicarbonyl compound, and a nucleophile in water
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DOI: 10.1039/c7gc03644b
Abstract: Three-component reactions of alkylglyoxals, 1,3-dicarbonyl compounds, and a nucleophile were performed under aqueous and catalyst-free conditions, which produced 1,4-diketone scaffolds in a straightforward way. Many compounds, such as indole, azaindole, pyrrole, 2-methylfuran, N,N-dimethylaniline, N-methylaniline, thiophenol,… read more here.
Keywords: diketones via; via three; facile synthesis; synthesis diketones ... See more keywords
Continuous mutation of SARS-CoV-2 during migration via three routes at the beginning of the pandemic
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DOI: 10.7717/peerj.12681
Abstract: Background It remains unclear how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection started, spread worldwide, and mutated to result in the present variants. This difficulty can be attributed to the limitations associated with the… read more here.
Keywords: three routes; continuous mutation; sars cov; via three ... See more keywords