Human CAFs promote lymphangiogenesis in ovarian cancer via the Hh-VEGF-C signaling axis.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18621
Abstract: Cancer-associated fibroblasts (CAFs) play a pivotal role in the development and progression of many human cancers. Recent studies have shown that Hedgehog (Hh) signalling modulates the stromal microenvironment and prepares a suitable niche for tumour… read more here.
Keywords: lymphangiogenesis; via vegf; cafs; ovarian cancer ... See more keywords
Sonic hedgehog promotes endothelial differentiation of bone marrow mesenchymal stem cells via VEGF-D.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of thoracic disease"
DOI: 10.21037/jtd.2018.09.50
Abstract: Background Bone marrow-derived mesenchymal stem cells (BMSCs) have been proved to be capable of differentiating into endothelial cells (ECs), however, the differentiation efficiency is rather low. Sonic hedgehog (Shh), an important factor in vascular development… read more here.
Keywords: via vegf; shh; differentiation; factor ... See more keywords