Vicinal Diamines as Smart Cosubstrates in the Transaminase-Catalyzed Asymmetric Amination of Ketones
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DOI: 10.1002/ejoc.201700253
Abstract: Transaminases (TAs) have recently been established as catalysts for the asymmetric, reductive amination of prochiral ketones. Depending on the ketone substrate and the amine donor (the cosubstrate), equilibrium constants may limit high conversions; thus, methods… read more here.
Keywords: cosubstrates transaminase; diamines smart; transaminase catalyzed; smart cosubstrates ... See more keywords
One-Pot Aminoalkylation of Aldehydes: Diastereoselective Synthesis of Vicinal Diamines with Azaarylmethylamines.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03287
Abstract: A one-pot synthesis of vicinal diamines with azaarylmethylamines and aldehydes is reported. A diverse array of vicinal diamines could be achieved in up to 92% yield with good to excellent diastereoselectivities (up to 20:1). The… read more here.
Keywords: synthesis vicinal; diamines azaarylmethylamines; vicinal diamines; one pot ... See more keywords
Photoredox-Catalyzed Radical Relay Reaction Toward Functionalized Vicinal Diamines
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DOI: 10.1055/s-0037-1609844
Abstract: A strategy has been described to synthesize β,γ-diaminoketones. This strategy is enabled by photoredox-catalyzed and nitrogen-centered radical-triggered cascade reactions of styrenes, enamides, and O-acylhydroxylamines in DMSO. Four bonds (one C–C, one C–N, and two C–O)… read more here.
Keywords: relay reaction; vicinal diamines; photoredox catalyzed; functionalized vicinal ... See more keywords