Polymorphisms in the APOBEC3G gene of Chinese rhesus macaques affect resistance to ubiquitination and degradation mediated by HIV-2 Vif
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DOI: 10.1007/s00705-019-04194-0
Abstract: Animal cells have multiple innate effector mechanisms that inhibit viral replication. For the pathogenic retrovirus human immunodeficiency virus 1 (HIV-1), there are widely expressed restriction factors, such as APOBEC3 proteins, tetherin/BST2, SAMHD1 and MX2, as… read more here.
Keywords: degradation; hiv; vif; rhesus macaques ... See more keywords
Polymorphisms of the cytidine deaminase APOBEC3F have different HIV-1 restriction efficiencies.
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DOI: 10.1016/j.virol.2018.11.004
Abstract: The APOBEC3 enzyme family are host restriction factors that induce mutagenesis of HIV-1 proviral genomes through the deamination of cytosine to form uracil in nascent single-stranded (-)DNA. HIV-1 suppresses APOBEC3 activity through the HIV-1 protein… read more here.
Keywords: restriction; apobec3f 108; hiv; vif ... See more keywords
Identification of small molecule compounds targeting the interaction of HIV-1 Vif and human APOBEC3G by virtual screening and biological evaluation
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DOI: 10.1038/s41598-018-26318-3
Abstract: Human APOBEC3G (hA3G) is a restriction factor that inhibits human immunodeficiency 1 virus (HIV-1) replication. The virally encoded protein Vif binds to hA3G and induces its degradation, thereby counteracting the antiviral activity of hA3G. Vif-mediated… read more here.
Keywords: human apobec3g; small molecule; interaction; vif ... See more keywords
Production of breast cancer cell lines expressing viral gene VIF
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DOI: 10.1080/07853890.2018.1561805
Abstract: Introduction: Virion Infectivity factor (Vif) is a protein required for lentiviruses successful infection of human target cells, through the degradation of host restriction factors, APOBEC3 [1]. In the last years, the activity of APOBEC3 deaminases… read more here.
Keywords: breast; breast cancer; vif; gene ... See more keywords
Structural basis for recruitment of host CypA and E3 ubiquitin ligase by maedi-visna virus Vif
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DOI: 10.1126/sciadv.add3422
Abstract: Lentiviral Vif molecules target the host antiviral APOBEC3 proteins for destruction in cellular ubiquitin-proteasome pathways. Different lentiviral Vifs have evolved to use the same canonical E3 ubiquitin ligase complexes, along with distinct noncanonical host cofactors… read more here.
Keywords: ubiquitin ligase; maedi visna; vif; ligase ... See more keywords
Conserved Interaction of Lentiviral Vif Molecules with HIV-1 Gag and Differential Effects of Species-Specific Vif on Virus Production
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DOI: 10.1128/jvi.00064-17
Abstract: ABSTRACT The virion infectivity factor (Vif) open reading frame is conserved among most lentiviruses. Vif molecules contribute to viral replication by inactivating host antiviral factors, the APOBEC3 cytidine deaminases. However, various species of lentiviral Vif… read more here.
Keywords: pr55gag; biv vif; vif; interaction ... See more keywords
Dominant Negative Mutants of Human Immunodeficiency Virus Type 1 Viral Infectivity Factor (Vif) Disrupt Core-Binding Factor Beta-Vif Interaction
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DOI: 10.1128/jvi.00555-22
Abstract: Antiviral therapy cannot eliminate HIV and exhibits disadvantages such as drug resistance and toxicity. Therefore, novel strategies for inhibiting viral replication in patients with HIV are urgently needed. ABSTRACT Apolipoprotein B mRNA-editing catalytic polypeptide-like 3… read more here.
Keywords: hiv; viral replication; vif; factor ... See more keywords
Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated Using Patient HIV-1 Isolates and Computational Modeling
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DOI: 10.1128/jvi.00631-20
Abstract: A critical function of HIV-1 Vif is to counteract the family of APOBEC3 innate immune proteins. It is also widely accepted that Vif induces G2/M cell cycle arrest in several different cell types. Recently, it… read more here.
Keywords: vif; hiv; hiv vif; degradation ... See more keywords
Identification of a conserved interface of HIV-1 and FIV Vifs with Cullin 5
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DOI: 10.1128/jvi.01697-17
Abstract: Members of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC3 [A3]) family of DNA cytidine deaminases are intrinsic restriction factors against retroviruses. In felids such as the domestic cat (Felis catus), the A3 genes encode… read more here.
Keywords: hiv; fiv; cul5; vif ... See more keywords
HIV-1 Vif Gained Breadth in APOBEC3G Specificity after Cross-Species Transmission of Its Precursors
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DOI: 10.1128/jvi.02071-21
Abstract: APOBEC3G (A3G) is an antiviral protein that potently restricts retroviruses like HIV. In turn, the HIV-1 protein Vif has evolved to antagonize A3G through degradation. ABSTRACT APOBEC3G (A3G) is a host-encoded cytidine deaminase that potently… read more here.
Keywords: cross species; a3g; species transmission; vif ... See more keywords
HIV-1 Escape from Small-Molecule Antagonism of Vif
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DOI: 10.1128/mbio.00144-19
Abstract: Although antiretroviral therapy can suppress HIV-1 replication effectively, virus reservoirs persist in infected individuals and virus replication rapidly rebounds if therapy is interrupted. Currently, there is a need for therapeutic approaches that eliminate, reduce, or… read more here.
Keywords: small molecule; hiv; virus replication; vif ... See more keywords