Pharmacokinetic evaluation of vigabatrin dose for the treatment of refractory focal seizures in children using adult and pediatric data
Sign Up to like & getrecommendations! Published in 2019 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2019.01.002
Abstract: Vigabatrin is indicated as adjunctive therapy for refractory focal seizures. For children, European recommendations indicate maintenance doses varying from 30 to 100 mg/kg/day for this indication. Since cumulated dose was associated with retinal toxicity, it is… read more here.
Keywords: adult; seizures children; focal seizures; refractory focal ... See more keywords
A Placebo-Controlled Randomized Trial of Vigabatrin in the Management of Acute Alcohol Withdrawal.
Sign Up to like & getrecommendations! Published in 2022 at "Alcohol and alcoholism"
DOI: 10.1093/alcalc/agac044
Abstract: OBJECTIVE To undertake a double blinded randomised placebo-controlled trial to assess the efficacy of vigabatrin, a GABA-transaminase inhibitor, as a benzodiazepine sparing agent in the management of acute alcohol withdrawal syndrome in a residential setting.… read more here.
Keywords: alcohol withdrawal; arm; withdrawal; management ... See more keywords
Reply: Rational therapy with vigabatrin and a ketogenic diet in a patient with GAD1 deficiency
Sign Up to like & getrecommendations! Published in 2020 at "Brain"
DOI: 10.1093/brain/awaa290
Abstract: In their letter, von Hardenberg et al. (2020) describe a female infant with mild malformations and neonatal onset seizures with a burst-suppression pattern on EEG, in whom they identified a novel homozygous splice-site variant in… read more here.
Keywords: von hardenberg; ketogenic diet; vigabatrin; hardenberg 2020 ... See more keywords