Vomiting and constipation associated with tramadol and codeine: a comparative study in VigiBase®
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DOI: 10.1007/s00228-018-2536-z
Abstract: The most frequent adverse drug reactions (ADRs) of codeine and tramadol, the two main step 2 opioid analgesics, include nausea, dizziness, sedation, vomiting, and constipation [1]. The relative importance of vomiting and constipation remains discussed… read more here.
Keywords: codeine; tramadol; vigibase; study ... See more keywords
Uncovering Pregnancy Exposures in Pharmacovigilance Case Report Databases: A Comprehensive Evaluation of the VigiBase Pregnancy Algorithm
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DOI: 10.1007/s40264-025-01559-0
Abstract: Information on the safety of medicine use during pregnancy is limited at the time of marketing, making post-marketing surveillance essential. However, the lack of a specific indicator for pregnancy-related case reports within the international standard… read more here.
Keywords: information; dataset; pregnancy; case ... See more keywords
Clozapine may consistently protect from suicidal behaviors while other antipsychotics may lack a specific protective effect: a comprehensive VigiBase study interpreted in the context of the prior literature
Sign Up to like & getrecommendations! Published in 2024 at "Expert Opinion on Drug Safety"
DOI: 10.1080/14740338.2024.2399094
Abstract: ABSTRACT Background In the United States, clozapine was first approved for treatment-resistant schizophrenia and then for suicidality in schizophrenia psychoses. Systematic reviews support clozapine’s anti-suicidal effect, but the forensic literature stresses its lethality during overdoses.… read more here.
Keywords: clozapine may; prior literature; vigibase; clozapine ... See more keywords
Clozapine-treated patients and myocardial infarction in adults: a pharmacovigilance study in VigiBase interpreted in the context of the literature.
Sign Up to like & getrecommendations! Published in 2025 at "Expert opinion on drug safety"
DOI: 10.1080/14740338.2025.2518234
Abstract: BACKGROUND Clozapine is the best treatment for treatment-resistant schizophrenia (TRS) but is associated with metabolic adverse drug reactions (ADRs). RESEARCH DOSING/METHODS The international pharmacovigilance database (VigiBase) uses the information component (IC) as a disproportionality analysis.… read more here.
Keywords: treated patients; myocardial infarction; clozapine treated; pharmacovigilance ... See more keywords
Association between myocarditis and antipsychotics other than clozapine: a systematic literature review and a pharmacovigilance study using VigiBase
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Clinical Pharmacology"
DOI: 10.1080/17512433.2022.2032659
Abstract: ABSTRACT Introduction Pharmacovigilance studies have definitely established that clozapine can cause myocarditis. Two published reviews suggested that on rare occasions other antipsychotics may induce myocarditis. Areas covered This review explored myocarditis associated with antipsychotics other… read more here.
Keywords: review; pharmacovigilance; literature; antipsychotics clozapine ... See more keywords
OP0237 THROMBOEMBOLIC SAFETY PROFILE OF TOFACITINIB AND BARICITINIB: AN ANALYSIS OF WHO VIGIBASE
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-eular.2823
Abstract: The Janus Kinase (JAK) inhibitors tofacitinib and baricitinib are new targeted treatments for rheumatoid arthritis. Recent concerns regarding the risk of thrombosis have led to warnings by the European Medicines Agency (EMA) and the Food… read more here.
Keywords: ror; vigibase; risk; baricitinib ... See more keywords
Association between exposure to proton pump inhibitors and hypertension: a descriptive and disproportionality analysis of VigiBase
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DOI: 10.1136/bmjopen-2025-105962
Abstract: Objectives The potential link between proton pump inhibitors (PPIs) and hypertension remains unclear. It is uncertain whether such an association exists, whether it represents a class-of-PPI effect and whether a dose–response relationship is involved. This… read more here.
Keywords: proton pump; association; hypertension; dose response ... See more keywords
Hepatic disorders associated with the use of Ivermectin for SARS-CoV-2 infection in adults: a pharmacovigilance study in VigiBase
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DOI: 10.22037/ghfbb.v15i4.2383
Abstract: Aim: The aim of the present study was to review in VigiBase the reports of serious hepatic disorders associated with the use of ivermectin for COVID-19 in adults. Background: In the face of the global… read more here.
Keywords: disorders associated; use ivermectin; vigibase; ivermectin ... See more keywords
Adverse events reported from the COVID-19 vaccines: A descriptive study based on the WHO database (VigiBase®)
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Applied Pharmaceutical Science"
DOI: 10.7324/japs.2021.110801
Abstract: The emergency approval of a few COVID-19 vaccines provided a ray of hope to fight the deadly pandemic. However, their approval was solely based on limited data from the clinical trials in a short period,… read more here.
Keywords: database; vigibase; study; adverse events ... See more keywords