Factor VIII mutated with Lys1813Ala within the factor IXa-binding region enhances intrinsic coagulation potential
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DOI: 10.1182/bloodadvances.2022008187
Abstract: Key Points • K1813 in the FVIII A3 domain, considered to be an FXa-binding site, is responsible for the A2 subunit dissociation of FVIIIa.• The FVIII-K1813A mutant showed higher global coagulation potential vs WT because… read more here.
Keywords: mutated lys1813ala; viii mutated; factor; factor viii ... See more keywords