Novel Vilazodone-Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation.
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DOI: 10.1021/acschemneuro.7b00259
Abstract: Depression is one of the most frequent psychiatric complications of Alzheimer's disease (AD), affecting up to 50% of the patients. A novel series of hybrid molecules were designed and synthesized by combining the pharmacophoric features… read more here.
Keywords: potential multitarget; vilazodone tacrine; depression; alzheimer disease ... See more keywords