Vildagliptin‐Derived Dipeptidyl Peptidase 9 (DPP9) Inhibitors: Identification of a DPP8/9‐Specific Lead
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DOI: 10.1002/cmdc.202200097
Abstract: Vildagliptin is a marketed DPP4 inhibitor, used in the management of type 2 diabetes. The molecule also has notable DPP8/9 affinity, with some preference for DPP9. Therefore, we aimed to use vildagliptin as a starting… read more here.
Keywords: dpp8; vildagliptin; dipeptidyl peptidase; derived dipeptidyl ... See more keywords
Protective effect of vildagliptin on TNF‐α‐induced chondrocyte senescence
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DOI: 10.1002/iub.2049
Abstract: Osteoarthritis (OA) is a common age‐related disorder. Chondrocytes in joint tissue play a critical role in normal articular cartilage function and tissue homeostasis. Local inflammatory cytokine‐induced chondrocyte senescence contributes to the development and progression of… read more here.
Keywords: tnf induced; vildagliptin; senescence; induced chondrocyte ... See more keywords
Efficacy of different antidiabetic drugs based on metformin in the treatment of type 2 diabetes mellitus: A network meta‐analysis involving eight eligible randomized‐controlled trials
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DOI: 10.1002/jcp.27097
Abstract: Diabetes mellitus is one of the most prevalent metabolic diseases globally and it is increasing in prevalence. It is one of the most expensive diseases with respect to total health care costs per patient as… read more here.
Keywords: treatment; metformin; vildagliptin; diabetes mellitus ... See more keywords
The DPP-4 inhibitor vildagliptin impacts the gut microbiota and prevents disruption of intestinal homeostasis induced by a Western diet in mice
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DOI: 10.1007/s00125-018-4647-6
Abstract: Aims/hypothesisDipeptidyl peptidase 4 (DPP-4) inhibitors are agents designed to increase the half-life of incretins. Although they are administered orally, little is known about their effects on the gut microbiota and functions, despite the fact that… read more here.
Keywords: vildagliptin; dpp; gut microbiota; mice ... See more keywords
Pretreatment with vildagliptin boosts ischemic-postconditioning effects on cardioprotection and expression profile of genes regulating autophagy and mitochondrial fission/fusion in diabetic heart with reperfusion injury
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DOI: 10.1007/s00210-019-01660-z
Abstract: The burden of myocardial ischemia/reperfusion (IR) injury is 2–3-folds higher in diabetic patients, so protecting diabetic hearts is clinically important. Here, we investigated the effect of combinational therapy with vildagliptin and ischemic postconditioning (IPostC) on… read more here.
Keywords: diabetic hearts; vildagliptin; reperfusion; expression ... See more keywords
The Role of Vildagliptin in the Therapy of Type 2 Diabetic Patients with Renal Dysfunction
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DOI: 10.1007/s13300-017-0302-3
Abstract: Diabetes is the leading cause of chronic kidney disease, and even in the absence of albuminuria, decreased renal function in type 2 diabetes mellitus (T2DM) patients increases the risk for major adverse cardiovascular events and… read more here.
Keywords: role vildagliptin; therapy type; vildagliptin; vildagliptin therapy ... See more keywords
Synthesis of vildagliptin conjugated metal nanoparticles for type II diabetes control: targeting the DPP-IV enzyme
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DOI: 10.1039/d0nj04202a
Abstract: Diabetes is one of the most prevalent diseases worldwide. Vildagliptin is a drug which overcomes the existing problems of anti-diabetic drugs. However, the short half-life (2–3 h) of vildagliptin remains an important concern. Recently there… read more here.
Keywords: synthesis vildagliptin; metal nanoparticles; vildagliptin; drug ... See more keywords
Innovative spectrofluorimetric determination of vildagliptin based on a “switch off/on” NS-doped carbon dot nanosensor
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DOI: 10.1039/d2ra04991k
Abstract: A simple, fast, and green one-step microwave pyrolysis approach was proposed for the synthesis of highly fluorescent nitrogen/sulfur-doped carbon dots (NS-CDs). The proposed NS-CDs were prepared in only one minute from citric acid and thiosemicarbazide.… read more here.
Keywords: vildagliptin; vildagliptin based; determination vildagliptin; determination ... See more keywords
Renoprotective effect of vildagliptin following hepatic ischemia/reperfusion injury
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DOI: 10.1080/0886022x.2020.1729189
Abstract: Abstract Remote renal injury is a drastic consequence of hepatic ischemia/reperfusion (IR) injury. Vildagliptin (V) is a dipeptidyl peptidase-4 inhibitor that has a hepatorenal protective effect against models of liver and renal IR. This research… read more here.
Keywords: renal injury; hepatic ischemia; following hepatic; injury ... See more keywords
Effectiveness of Vildagliptin in Clinical Practice: Pooled Analysis of Three Korean Observational Studies (the VICTORY Study)
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DOI: 10.1155/2017/5282343
Abstract: The present observational study aimed to evaluate the clinical effectiveness of vildagliptin with metformin in Korean patients with type 2 diabetes mellitus (T2DM). Data were pooled from the vildagliptin postmarketing survey (PMS), the vildagliptin/metformin fixed… read more here.
Keywords: analysis; vildagliptin; study; versus ... See more keywords
Formulation, In Vitro Evaluation, and Toxicity Studies of A. vulgaris-co-AAm Carrier for Vildagliptin
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DOI: 10.1155/2021/6634780
Abstract: This study investigated the use of Artemisia vulgaris L. seed mucilage as a new excipient for sustained delivery of Vildagliptin. Copolymeric carrier of A. vulgaris seed mucilage-co-AAm was devised by using acrylamide (AAm) as a… read more here.
Keywords: seed; vildagliptin; vulgaris aam; reaction temperature ... See more keywords