Spatial Reconstruction of Single Enterocytes Uncovers Broad Zonation along the Intestinal Villus Axis
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DOI: 10.1016/j.cell.2018.08.063
Abstract: The intestinal epithelium is a highly structured tissue composed of repeating crypt-villus units. Enterocytes perform the diverse tasks of absorbing a wide range of nutrients while protecting the body from the harsh bacterium-rich environment. It… read more here.
Keywords: spatial reconstruction; broad zonation; villus axis; zonation ... See more keywords
Lgr5+ telocytes are a signaling source at the intestinal villus tip
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DOI: 10.1038/s41467-020-15714-x
Abstract: The intestinal epithelium is a structured organ composed of crypts harboring Lgr5+ stem cells, and villi harboring differentiated cells. Spatial transcriptomics have demonstrated profound zonation of epithelial gene expression along the villus axis, but the… read more here.
Keywords: villus axis; lgr5 telocytes; villus tip; expression ... See more keywords