Facile and efficient access to Androsten-17-(1',3',4')-pyrazoles and Androst-17β-(1',3',4')-pyrazoles via Vilsmeier reagents, and their antiproliferative activity evaluation in vitro.
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DOI: 10.1016/j.ejmech.2017.02.033
Abstract: In this work, twenty-seven novel steroidal pyrazole derivatives were designed and effectively synthesized with two different commercially available staring material, Isopregnanolone 1 and 5,16-Pregnadienolone 7, via the key intermediates, 17β-(4'-formyl)pyrazolylandrost-3β-yl formate and 17-(4'-formyl)pyrazolylandrost- 5,16-dienes-3β-yl formate,… read more here.
Keywords: cell lines; facile efficient; efficient access; vilsmeier ... See more keywords