1,2,4-Triazole-3-Thione Analogues with a 2-Ethylbenzoic Acid at Position 4 as VIM-type Metallo-β-Lactamase Inhibitors.
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DOI: 10.1002/cmdc.202100699
Abstract: Metallo-β-lactamases (MBLs) are increasingly involved as a major mechanism of resistance to carbapenems in relevant opportunistic Gram-negative pathogens. Unfortunately, clinically efficient MBL inhibitors still represent an unmet medical need . We previously reported several series… read more here.
Keywords: triazole thione; metallo; vim; vim type ... See more keywords
Emergence and spread of VIM-type metallo-β-lactamase-producing Pseudomonas aeruginosa clinical isolates in Japan.
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DOI: 10.1016/j.jgar.2020.09.010
Abstract: OBJECTIVES The aim of this study was to determine the genetic and epidemiological properties of Pseudomonas aeruginosa strains producing VIM-type metallo-β-lactamases (MBLs) isolated from patients in Japan. METHODS A total of 1,860 clinical isolates of… read more here.
Keywords: blavim blavim; pseudomonas aeruginosa; vim; vim type ... See more keywords
Genetic diversity, biochemical properties, epidemiology, and detection methods of IMP- and VIM-type carbapenemases
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DOI: 10.1128/cmr.00129-23
Abstract: SUMMARY Metallo-beta-lactamases are an ever-growing problem. Since the discovery of the beta-lactamase of Bacillus cereus in the late 1960s, many class B beta-lactamases have been reported, with three main families being NDM-, IMP-, and VIM-like.… read more here.
Keywords: epidemiology; genetic diversity; vim type; type carbapenemases ... See more keywords