Intergenerational response to the endocrine disruptor vinclozolin is influenced by maternal genotype and crossing scheme.
Sign Up to like & getrecommendations! Published in 2018 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2018.03.005
Abstract: In utero exposure to vinclozolin (VIN), an antiandrogenic fungicide, is linked to multigenerational phenotypic and epigenetic effects. Mechanisms remain unclear. We assessed the role of antiandrogenic activity and DNA sequence context by comparing effects of… read more here.
Keywords: intergenerational response; response endocrine; antiandrogenic activity; response ... See more keywords
Vinclozolin-induced mouse penile malformation and "small testis" via miR132, miR195a together with the Hippo signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology"
DOI: 10.1016/j.tox.2021.152842
Abstract: Vinclozolin (VCZ) is a fungicide with antiandrogen activity. Exposure to VCZ in maternal uterus may cause uterine, ovarian and testicular damage, hypospadias and prostate abnormality in the offspring. Hippo pathway, which is highly conservative and… read more here.
Keywords: penile malformation; mir132 mir195a; vinclozolin; vcz ... See more keywords
In vitro phase I metabolism of vinclozolin by human liver microsomes
Sign Up to like & getrecommendations! Published in 2019 at "Xenobiotica"
DOI: 10.1080/00498254.2018.1523485
Abstract: Abstract 1. Vinclozolin (Vin) is a fungicide used in agricultural settings and is classified as an endocrine disruptor. Vin is non-enzymatically hydrolyzed to 2-[[(3,5-dichlorophenyl)-carbamoyl]oxy]-2-methyl-3-butenoic acid (M1) and 3',5'-dichloro-2-hydroxy-2-methylbut-3-enanilide (M2) metabolites. There is no information about Vin… read more here.
Keywords: metabolism; vinclozolin; vin; liver microsomes ... See more keywords
Effects of Fungicides on Rat's Neurosteroid Synthetic Enzymes
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DOI: 10.1155/2017/5829756
Abstract: Exposure to environmental endocrine disruptors may interfere with nervous system's activity. Fungicides such as tebuconazole, triadimefon, and vinclozolin have antifungal activities and are used to prevent fungal infections in agricultural plants. In the present study,… read more here.
Keywords: tebuconazole triadimefon; hsd; effects fungicides; triadimefon ... See more keywords
Chronic Exposure to Vinclozolin Induced Fibrosis, Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis in Mice Kidney
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911296
Abstract: Vinclozolin is one of the most used fungicides in the control of fungi in fruits, vegetables, and ornamental plants. The effects of its exposure on different organs have been described, but information regarding its relevance… read more here.
Keywords: vinclozolin; vinclozolin induced; kidney; oxidative stress ... See more keywords
Chronic Exposure to Endocrine Disruptor Vinclozolin Leads to Lung Damage via Nrf2–Nf-kb Pathway Alterations
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911320
Abstract: Endocrine-disrupting substances (EDS) are common and pervasive in our environment and pose a serious risk to both human and animal health. Endocrine-disrupting compounds (EDCs) have been associated with a variety of detrimental human health effects,… read more here.
Keywords: vinclozolin; endocrine disruptor; exposure endocrine; chronic exposure ... See more keywords