Beneficial effects of quercetin on vincristine‐induced liver injury in rats: Modulating the levels of Nrf2/HO‐1, NF‐kB/STAT3, and SIRT1/PGC‐1α
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23326
Abstract: Our experimental objective was to investigate the hepatotoxic effect of vincristine (VCR) administration in rats and determined whether combined therapy with Quercetin (Quer) ensured protection. Five groups with seven rats each were used for this… read more here.
Keywords: sirt1 pgc; vincristine; vcr; levels nrf2 ... See more keywords
Intratumoral recombinant human interferon alpha‐2a and vincristine combination therapy in canine transmissible venereal tumour
Sign Up to like & getrecommendations! Published in 2018 at "Veterinary Medicine and Science"
DOI: 10.1002/vms3.119
Abstract: Canine transmissible venereal tumour (CTVT) is a naturally occurring contagious neoplasm of dogs located mainly on the external genitalia of both sexes. The course of vincristine chemotherapy, the most effective and practical therapy, is affected… read more here.
Keywords: combination; vincristine treatment; group; therapy ... See more keywords
Prokineticin 2 promotes and sustains neuroinflammation in vincristine treated mice: Focus on pain and emotional like behavior
Sign Up to like & getrecommendations! Published in 2019 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2019.09.012
Abstract: Vincristine (VCR) treatment is often associated to painful neuropathy. Its development is independent from antitumoral mechanism and involves neuroinflammation. We investigated the role of the chemokine prokineticin (PK)2 in a mouse model of VCR induced… read more here.
Keywords: neuroinflammation; emotional like; day; vincristine ... See more keywords
A highly sensitive bioanalytical method for the quantification of vinblastine, vincristine, vinorelbine and 4-O-deacetylvinorelbine in human plasma using LC-MS/MS.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2022.114772
Abstract: A highly sensitive method was developed for the quantification of vinblastine, vincristine, vinorelbine, and its active metabolite 4-O-deacetylvinorelbine in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Deuterated isotopes were used as internal standard and… read more here.
Keywords: deacetylvinorelbine; vinorelbine deacetylvinorelbine; vincristine; highly sensitive ... See more keywords
Vincristine-induced peripheral neuropathy: a mini-review.
Sign Up to like & getrecommendations! Published in 2020 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2020.10.004
Abstract: Vincristine (VCR), an alkaloid extracted from vinca, is often used in combination with other chemotherapeutic drugs to treat a variety of cancers, such as acute lymphoblastic leukaemia (ALL), malignant lymphoma, and neuroblastoma. However, VCR possesses… read more here.
Keywords: peripheral neuropathy; neuropathy mini; vincristine induced; induced peripheral ... See more keywords
Diethylhexyl Phthalate and Bisphenol A Promote Vincristine and Tamoxifen Resistance in Vitro.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00002
Abstract: Environmental estrogen active compounds are strong determinants of estrogen receptor (ER)-positive breast cancers, and increased evidence indicates their contribution to chemotherapy resistance. In the current study, the efficacy of vincristine and tamoxifen, with the presence… read more here.
Keywords: estrogen; vincristine; resistance; diethylhexyl phthalate ... See more keywords
A Metabolomics Approach for Early Prediction of Vincristine-Induced Peripheral Neuropathy
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-66815-y
Abstract: Vincristine is a core chemotherapeutic drug administered to pediatric acute lymphoblastic leukemia patients. Despite its efficacy in treating leukemia, it can lead to severe peripheral neuropathy in a subgroup of the patients. Peripheral neuropathy is… read more here.
Keywords: approach early; metabolomics approach; peripheral neuropathy; vincristine ... See more keywords
Incidence of vincristine induced neurotoxicity in children with acute lymphoblastic leukemia and its correlation with nutritional deficiencies
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Hematology and Oncology"
DOI: 10.1080/08880018.2019.1637981
Abstract: Abstract Injection vincristine is an important component of therapy for acute lymphoblastic leukemia (ALL). An important adverse effect of vincristine is neurotoxicity. The incidence of this adverse effect is well studied. The present was undertaken… read more here.
Keywords: vincristine induced; lymphoblastic leukemia; correlation; acute lymphoblastic ... See more keywords
Vincristine-induced neurotoxicity in pediatric patients with rhabdomyosarcoma: A retrospective analysis of clinical features and outcome
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Hematology and Oncology"
DOI: 10.1080/08880018.2022.2047849
Abstract: Abstract Vincristine is an essential component of rhabdomyosarcoma treatment. However, it can cause motor neurotoxicity, necessitating dose reductions. We retrospectively reviewed the rates and patterns of vincristine-induced motor neuropathy in children treated for rhabdomyosarcoma, and… read more here.
Keywords: induced neurotoxicity; vincristine; vincristine induced; neurotoxicity pediatric ... See more keywords
Hepatotoxic effect of subacute vincristine administration activates necrosis and intrinsic apoptosis in rats: protective roles of broccoli and Indian mustard
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Physiology and Biochemistry"
DOI: 10.1080/13813455.2018.1427765
Abstract: Abstract This study investigated the hepatotoxic effect of long-term vincristine (VCR) administration in rats and to assess if an individual or combined therapy with Indian mustard and broccoli afforded protection. Signs of hepatotoxicity, including altered… read more here.
Keywords: indian mustard; administration; hepatotoxic effect; mustard ... See more keywords
The impact of vincristine on testicular development and function in childhood cancer
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DOI: 10.1093/humupd/dmac039
Abstract: Abstract BACKGROUND Increasing childhood cancer survival rates in recent decades have led to an increased focus on fertility as a long-term complication of cancer treatment. Male childhood cancer survivors often face compromised testicular function as… read more here.
Keywords: function; vincristine; fertility; analysis ... See more keywords